ArticleBiological trace element research2026
Bioinformatics-Based Discovery of Therapeutic Targets in Cadmium-Induced Lung Adenocarcinoma: The Role of Oxyresveratrol.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Physical activity and oxidative stress biomarkers in humans: a systematic review and quantitative meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Ginkgo biloba as a Promising Candidate for Traumatic Brain Injury: Insights From Preclinical and Clinical Studies.Chemistry & biodiversity · 2026Pooled it
- Integrative Transcriptomic, Network, and Machine Learning Analyses Identify Genistein and Resveratrol-Associated Therapeutic Targets in Alzheimer's Disease.Molecular neurobiology · 2026Article
- Network-based discovery of gene-miRNA interactions associated with hepatocellular carcinoma.Irish journal of medical science · 2026Article
- Resveratrol potentiates chemotherapeutic efficacy of olaparib in MCF7 human breast cancer cells by inducing apoptosis.Irish journal of medical science · 2026Article
- Integrated bioinformatics and molecular docking ıdentify CCNB1, CDK1, and CYP1A2 as therapeutic targets of phytochemicals in hepatocellular carcinoma.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Inhibitory Mechanism of Buyang Huanwu Decoction on AGE/RAGE Pathway in Membranous Nephropathy: Integration of Network Pharmacology and Cell Model Validation.International journal of general medicine · 2026Article
- Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data.Frontiers in immunology · 2026Article
- Radioprotective Efficacy of Jujube Aqueous Extract and Arbutin: Synergistic Antioxidant and Anti-Apoptotic Mechanisms in Radiation Injury.Food science & nutrition · 2025Article
- Network Pharmacology and Molecular Docking Elucidate the Mechanism of Phillyrin in Colorectal Cancer.Food science & nutrition · 2025Article
- Integrative Multi-Omics Analysis and Experiments Validation Identify COX5B as a Novel Therapeutic Target for Lung Adenocarcinoma.Oncology research · 2025Article
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3 authors.
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Abstract
In this study, we establish a comprehensive bioinformatic and experimental platform for revealing the molecular bases of cadmium (Cd)-induced lung adenocarcinoma (LUAD) and the therapeutic efficacy of the natural polyphenol oxyresveratrol (O-RES) against this disease. A total of 116 differentially expressed genes (DEGs) were obtained, including 30 upregulated and 86 downregulated obtained by integrating five LUAD-related transcriptomic datasets from the GEO database. Results of network analysis identified four core hub genes: upregulated (Mmp9 and Col1a1) and downregulated (Cdh5 and Pecam-1). Using the ToppFUN module, functional enrichment analysis described the identified genes in relevant oncogenic. The in vivo validation with a rat model of Cd-induced lung toxicity further confirmed that the expression levels of these hub genes were markedly changed due to the increased level of Cd, which resembled the human LUAD profile. Strikingly, co-administration of oxyresveratrol (O-RES) further completely abolished the transcriptional aberration of this signaling pathway induced by Cd, indicating that O-RES could attenuate carcinogenic signaling in Cd-induced carcinogenesis. Furthermore, molecular docking analysis revealed that O-RES exhibits strong and specific binding affinities to key LUAD-associated targets, including Mmp9, Col1a1, Cdh5, and Pecam-1, supporting its multi-targeted therapeutic potential. These findings not only underscore the potential of Mmp9, Col1a1, Cdh5, and Pecam-1 as robust biomarkers for Cd-induced LUAD but also highlight O-RES as a promising multi-targeted agent for chemoprevention and therapeutic intervention in environmentally triggered LUAD.
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