Evidence map›Paper›PMID 40610691›Full record

ArticleAging clinical and experimental research2025

Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine.

Jiali Xiong, Lizhong Yin, Xia Li, Huiyan Wang, Bin Yu

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Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiali XiongDepartment of Obstetrics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, No.16 Ding Xiang Road, Changzhou, Jiangsu Province, China.
Lizhong YinDepartment of Obstetrics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, No.16 Ding Xiang Road, Changzhou, Jiangsu Province, China.
Xia LiDepartment of Women's Health, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, No.16 Ding Xiang Road, Changzhou, Jiangsu Province, China.
Huiyan WangDepartment of Obstetrics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, No.16 Ding Xiang Road, Changzhou, Jiangsu Province, China. huiyanwang@njmu.edu.cn.
Bin YuDepartment of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, No.16 Ding Xiang Road, Changzhou, Jiangsu Province, China. binyu@njmu.edu.cn.ORCID https://orcid.org/0000-0001-7796-7314

Funding

Applied Basic Research General Program of Changzhou Science and Technology Bureau CJ20220117Changzhou Medical Center Project of Nanjing Medical University CZKYCMCB202203Clinical frontier technology of Changzhou Health Commission QY202308Medical Center Project of Nanjing Medical University CMCC202410Project funding for the training of high-level health professionals in Changzhou 2022CZZY007Research project of Changzhou Maternal and Child Health Care Hospital YJ202402the Leading Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Talents Training Project 2022CZLJ023
6 · The paper itself

Abstract

objectiveTo clarify the association between daily sitting time and accelerated aging in women, and explored that systemic immune-inflammation index and creatinine together play an important mediating effect throughout the process.

methodsA total of 5578 women during 2007 to 2010 from the National Health and Nutrition Examination Survey was utilized in this study. Phenotypic age calculation, logistic regression analysis, restricted cubic spline model, and subgroup analysis were employed to investigate the association between daily sitting time and accelerated aging as well as its influencing factors.

resultsThe threshold effect analysis identified 7 h as the inflection point. For every hour of sitting above the inflection point, the risk of accelerated aging will increase by 12.00%. Logistic regression analysis indicated that, compared to women who spent less than 4 h being sedentary during the day, the risk of accelerated aging increased 49.0%, 77%, 110% in the women spent 4 ~ 6 h (OR = 1.49, 95%CI 1.18,1.88, p = 0.0008), 6 ~ 8 h(OR = 1.77, 95%CI 1.36, 2.28, p < 0.001) and at least 8 h(OR = 2.10, 95%CI 1.70, 2.61, p < 0.001) respectively. Restricted cubic spline models validated nonlinear associations between the systemic immune-inflammation index, creatinine, and accelerated aging (p for nonlinearity < 0.001). Parallel mediation analysis found that although systemic immune-inflammation index and creatinine had significant mediating effects (p < 0.001) in the process of daily sitting time leading to accelerated aging, and they were a parallel double mediation effect.

conclusionsProlonged sitting time is significantly associated with accelerated aging, systemic immune-inflammation index and creatinine levels play important mediating roles in this process.

Indexed as

AgingAging, PrematureCreatinineInflammationSedentary BehaviorSitting PositionAdultAgedFemaleHumansMiddle AgedNutrition SurveysTime FactorsCreatinineAccelerated agingCreatinineDaily sitting timeSedentary behaviorSystemic immune-inflammation index

Identifiers

PMID40610691
PMCPMC12226695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.