Evidence map›Paper›PMID 40610647›Full record

ArticleMikrochimica acta2025

Ultrasonic-assisted molecular probe for turn-on electrochemical and fluorescence dual-mode detection of GSH in human serum.

Ke Xu, Hui Dong, Zuying Wang, Weitian Chen, Yan Zhou, Menghao Cheng, Bingbing Du, Xiuhua Wei, Xu Zhu, Yanli Zhou and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ke XuCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Hui DongHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China. huidong607607@126.com.
Zuying WangCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Weitian ChenCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Yan ZhouHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Menghao ChengHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Bingbing DuHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Xiuhua WeiHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Xu ZhuHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Yanli ZhouHenan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint, International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Zhaohui LiCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Yintang ZhangCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Maotian XuCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.

Funding

Henan Provincial Natural Science Foundation grant no. 242300421208National Natural Science Foundation of China grant no. 22474072sponsored Program for Science & Technology Innovation Talents in Universities of Henan Province no. 24HASTIT003Supported by Program for Innovative Research Team (in Science and Technology) in University of Henan Province no. 24IRTSTHN003The Excellent Youth Fund Program of Supported by Natural Science Foundation of Henan Grant No. 232300421084
6 · The paper itself

Abstract

A molecular probe, 3-oxo-3H-phenoxazin-7-yl thiophene-2-carboxylate (RD), was synthesized using resorufin (Re) as the substrate for the specific recognition of glutathione (GSH). Ultrasonic waves were employed to enhance the reaction efficiency between the molecular probe and GSH. The molecular probe was designed to exhibit specific recognition ability for GSH. In the absence of GSH, the probe's fluorescence is quenched; in the presence of GSH, a specific reaction restores the fluorescence intensity, achieving "turn-on" fluorescence detection. The detection limit for GSH was 5.52 μM, with a linear range of 5 μM to 1.2 mM. Additionally, an electrochemical detection method was integrated. The interaction between GSH and the modified electrode surface induces a change in the electrochemical signal, which can be used for the quantitative determination  of GSH. The detection limit for GSH using this method was 8 μM, with a linear range of 10 μM to 1.2 mM. By combining these two detection modes, the reliability and accuracy of glutathione detection were significantly improved. Furthermore, the practical application of this method in human serum samples demonstrated its good selectivity and anti-interference ability, providing a reliable dual-mode analysis platform for clinical GSH detection.

Indexed as

Electrochemical TechniquesFluorescent DyesGlutathioneMolecular ProbesHumansLimit of DetectionSpectrometry, FluorescenceThiophenesUltrasonic WavesFluorescent DyesGlutathioneMolecular ProbesThiophenesDual mode detectionElectrochemical detectionFluorescentGlutathioneUltrasonic assisted reaction

Identifiers

PMID40610647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.