ArticleNPJ Parkinson's disease2025
Multiparametric quantitative MRI uncovers putamen microstructural changes in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Multimodal Quantitative MRI of White and Gray Matter: Associations with Myelin-Related Metrics in the Healthy Adult Brain Using Synthetic MRI and IVIM-DWI.Journal of clinical medicine · 2026Article
- In-vivo histology of Parkinson's disease using quantitative multiparametric mapping.NPJ Parkinson's disease · 2026Article
- Cortical Microstructural Variations Correlate With Individual Differences in Gamified Exploration-Exploitation Behaviours.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Multispectral 7 Tesla MRI as a potential predictor of dopamine transporter deficiency in Parkinson's disease.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder dominated by motor and non-motor dysfunction. Despite extensive research, in vivo characterization of PD-related brain microstructure remains a challenge, limiting diagnostic and therapeutic advances. The putamen, a subcortical region crucial for movement regulation, is prominently affected in early PD. Here, we collected multiparametric quantitative MRI (qMRI) data from PD patients and healthy controls, to investigate biophysical alterations in the putamen. Gradient analysis revealed significant spatial variation and interhemispheric asymmetries in biophysical properties - including relaxation rates (R1, R2, R2*), water fraction (WF), susceptibility, MTsat, and diffusion metrics (MD, FA) - along its anterior-posterior axis. PD patients showed altered gradients, particularly increased WF in the posterior putamen, suggesting tissue atrophy or neuroinflammation, and correlating with motor symptom laterality. Our findings highlight the posterior putamen as a PD pathology hotspot and demonstrate the potential of qMRI gradient analysis for detecting clinically relevant brain changes.
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Registered trials
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