Evidence map›Paper›PMID 40610513›Full record

ArticleScientific reports2025

Pituitary adenylate cyclase-activating polypeptide mediates bacterial endotoxin-induced fever via an effect on cyclooxygenase-2 and inflammatory cytokines.

Jason Sparks, Nora Furedi, Kata Fekete, Margit Solymar, Krisztina Pohoczky, Agnes Kemeny, Dora Reglodi, Andras Garami, Eszter Pakai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jason SparksHungarian Research Network (HUN-REN-PTE), PACAP Research Group, Department of Anatomy, Medical School, University of Pecs, Pecs, Hungary.
Nora FurediDepartment of Anatomy, Medical School, University of Pecs, Pecs, Hungary.
Kata FeketeDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Margit SolymarDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Krisztina PohoczkyDepartment of Pharmacology, Faculty of Pharmacy, University of Pecs, Pecs, Hungary.
Agnes KemenyDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, Pecs, Hungary.
Dora ReglodiHungarian Research Network (HUN-REN-PTE), PACAP Research Group, Department of Anatomy, Medical School, University of Pecs, Pecs, Hungary.
Andras GaramiDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary. andras.garami@aok.pte.hu.
Eszter PakaiDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A role for pituitary adenylate cyclase-activating polypeptide (PACAP) signaling was suggested in bacterial lipopolysaccharide (LPS)-induced fever, but the underlying mechanisms of how PACAP contributes to the febrile response have remained unclarified. We administered LPS (120 µg/kg, intraperitoneally) to mice with the Pacap gene either present (Pacap

Indexed as

Cyclooxygenase 2CytokinesFeverPituitary Adenylate Cyclase-Activating PolypeptideAnimalsLipopolysaccharidesLiverLungMaleMiceMice, Inbred C57BLMice, KnockoutCyclooxygenase 2CytokinesLipopolysaccharidesPituitary Adenylate Cyclase-Activating PolypeptidePtgs2 protein, mouseCOX-2FeverLPSPACAPSystemic inflammationThermoregulation

Identifiers

PMID40610513
PMCPMC12229556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.