Evidence map›Paper›PMID 40610502›Full record

ArticleScientific reports2025

Discovering molecular signatures in kidney transplant biopsies with borderline changes and isolated V-lesions: single-cell RNA-sequencing analysis of human blood and tissue Spatial transcriptomics.

Jeongin Song, Minji Kang, Yunyoung Jang, Christine Suh-Yun Joh, Ha Yeon Shin, Julia Young Baik, Hyun Seung Choi, Kyu Hong Kim, Seong Min Lee, Seung-Min Cha and 17 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Jeongin Song *Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang-si, South Korea.
Minji Kang *Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Yunyoung JangDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Christine Suh-Yun JohDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Ha Yeon ShinDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Julia Young BaikDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Hyun Seung ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Kyu Hong KimDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Seong Min LeeDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Seung-Min ChaDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Hyunah KuDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Ahram HanDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Sang Il MinDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Jongwon HaDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Kyung Chul MoonDepartment of Pathology, Seoul National University Hospital, Seoul, South Korea.
Sehoon ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Seung Seok HanDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Hajeong LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Dong Ki KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Kook Hwan OhDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Kwon Wook JooDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Ji Hwan MoonSamsung Genome Institute, Samsung Medical Center, Seoul, South Korea.
Chung-Gyu ParkDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Yon Su KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Seung Hee YangKidney Research Institute, Seoul National University Medical Research Center, Seoul, South Korea. ysh5794@gmail.com.
Hyun Je KimDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea. hjkim0518@gmail.com.
Yong Chul KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea. imyongkim@gmail.com.

Funding

Institute of Information & communications Technology Planning & Evaluation (IITP) NO.RS-2021-II211343Ministry of Science & ICT, SNUH researcher fund 0320230390
6 · The paper itself

Abstract

Acute T cell-mediated rejection (TCMR) is one of the most important causes of kidney graft injury and loss; however, in-depth transcriptomic analyses of relevant tissues and circulating immune cells are limited. In this study, we conducted single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear cells and spatial transcriptomics using kidney allograft biopsy samples. The scRNA-seq study included four patients with borderline rejection or biopsy-proven TCMR and two with no evidence of TCMR. For spatial analysis, we compared tissue specimens from one patient diagnosed with borderline rejection and another patient with TCMR to their time-zero protocol biopsies. Six regions of interest per biopsy section were selected, focusing on the evident T-cell infiltration area in the tubulointerstitium and glomeruli. Integrating two methodologies, we pinpointed CD8

Indexed as

Graft RejectionKidney TransplantationTranscriptomeAdultBiopsyCD8-Positive T-LymphocytesFemaleGene Expression ProfilingHumansKidneyLeukocytes, MononuclearMaleMiddle AgedSequence Analysis, RNASingle-Cell AnalysisSTAT1 Transcription FactorSTAT1 protein, humanSTAT1 Transcription FactorBorderline changeKidney allograft function/DysfunctionKidney transplantation/NephrologyRejectionT cell mediated rejectionTranslational research/Science

Identifiers

PMID40610502
PMCPMC12229537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.