ArticleNPJ Parkinson's disease2025
Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson's disease and related alpha-synucleinopathies.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Evaluating the Relationship Between Early Non-Motor Symptoms and Late Diagnosis of Parkinson's Disease Based on the PPMI Database From 2012 to 2018: A Retrospective Cross-Sectional Study.Health science reports · 2026Article
- Unmasking the Prodrome: A Deep-Learning Bridge to Precision Diagnostics in Rapid Eye Movement Sleep Behavior Disorder.Journal of clinical neurology (Seoul, Korea) · 2026Article
- The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder.Biomarkers in medicine · 2026Article
- Home-Based REM Sleep Without Atonia in Patients with Parkinson's Disease: A Post Hoc Analysis of the ZEAL Study.NeuroSci · 2026Article
- The Syn-Q study: detection of cutaneous phosphorylated alpha-synuclein in Parkinson's disease progression: a trial protocol.Frontiers in neurologyArticle
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Authors and funding
9 authors.
Funding
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Abstract
Isolated REM sleep behavior disorder (iRBD) is a prodromal marker of Parkinson's disease (PD) and related alpha-synucleinopathies. Identification of RBD is crucial for timely intervention and disease-modifying treatments. While video-polysomnography (vPSG) remains the diagnostic gold standard, its costly and resource-intensive nature limits its utility. This systematic review evaluates emerging non-PSG tools and modalities for home-based RBD detection. A systematic search of PubMed, Web of Science, and Cochrane Library identified 17 studies, categorized into actigraphy devices (n = 9), novel tools (n = 5), and emerging modalities (n = 3). Advances in actigraphy, through machine learning integration, have significantly improved RBD detection. Novel tools, including portable biopotential systems and temporary tattoo electrodes, show promise for home-based REM sleep without atonia monitoring, while contactless cameras demonstrate high sensitivity for dream-enacting behavior detection. Future studies for validation are needed, ensuring reliability and clinical applicability for large-scale screening efforts aimed at identifying individuals at risk for PD and related alpha-synucleinopathies.
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Registered trials
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