Evidence map›Paper›PMID 40610449›Full record

SynthesisNature communications2025

Respiratory syncytial virus hospitalisation by chronological month of age and by birth month in infants.

Ling Guo, Sebastien Kenmoe, Fuyu Miyake, Alexandria Chung, Han Zhang, Teresa Bandeira, Mauricio T Caballero, Jean-Sébastien Casalegno, Rodrigo Fasce, Chakhunashvili Giorgi and 17 more

Abstract readSystematic Review
In one paragraph

Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Maternal Influenza Vaccine Reduces the Risk of Respiratory Syncytial Virus and Related Respiratory Hospitalizations in Early Infancy: An Epidemiological Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
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  5. Review
  6. Article
  7. Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ling GuoDepartment of Epidemiology, National Vaccine Innovation Platform, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0009-0002-7081-8548
Sebastien KenmoeCentre for Global Health, Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Fuyu MiyakeCentre for Global Health, Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Alexandria ChungCentre for Global Health, Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5221-5570
Han ZhangDepartment of Epidemiology, National Vaccine Innovation Platform, School of Public Health, Nanjing Medical University, Nanjing, China.
Teresa BandeiraDepartment of Pediatrics, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
Mauricio T CaballeroCentro Infant de Medicina Traslacional (CIMeT), Escuela de Bio y Nanotecnología, Universidad Nacional de San Martin, San Martin, Argentina.ORCID http://orcid.org/0000-0002-4218-5942
Jean-Sébastien CasalegnoHospices Civils de Lyon, Hôpital de la Croix-Rousse, Centre de Biologie Nord, Institut des Agents Infectieux, Laboratoire de Virologie, Lyon, France.
Rodrigo FasceInstitute of Public Health, Santiago, Chile.
Chakhunashvili GiorgiNational Center for Disease Control and Public Health, Tbilisi, Georgia, USA.
Terho HeikkinenDepartment of Pediatrics, University of Turku, Turku, Finland.
Q Sue HuangInstitute of Environmental Science and Research, Upper Hutt, New Zealand.ORCID http://orcid.org/0000-0002-3923-5195
Esther Nyadzua KatamaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
James W KeckAlaska Native Tribal Health Consortium, Anchorage, AK, USA.
Enmei LiuDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China.
Josko MarkicDepartment of Pediatrics, University Hospital of Split, Split, Croatia.ORCID http://orcid.org/0000-0001-9469-9278
Hannah C MooreThe Kids Research Institute Australia, Perth, WA, Australia.
Jocelyn MoyesCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.
Barbara A RathVaccine Safety Initiative, Berlin, Germany.ORCID http://orcid.org/0000-0001-5181-8417
Candice RomeroCulmen International Company, Alexandria, VA, USA.
Qianli WangShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Marta WernerGrant Benavente Clinical Hospital, Concepción, Chile.
Chee Fu YungInfectious Disease Service, KK Women's and Children's Hospital, Singapore, Singapore.
Respiratory Virus Global Epidemiology Network
Harish Nair *Department of Epidemiology, National Vaccine Innovation Platform, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-9432-9100
You Li *Department of Epidemiology, National Vaccine Innovation Platform, School of Public Health, Nanjing Medical University, Nanjing, China. You.Li@njmu.edu.cn.ORCID http://orcid.org/0000-0002-8506-8439
PROMISE investigators

Funding

Gates Foundation INV-005318Innovative Medicines Initiative (IMI) 101034339
6 · The paper itself

Abstract

Understanding the distribution of respiratory syncytial virus (RSV) disease burden by more granular age bands in infants is necessary for optimising infant RSV immunisation strategies. Using a Bayesian model, we synthesised published data from a systematic literature review and unpublished data shared by international collaborators for estimating the distribution of infant RSV hospitalisations by month of age. Based on local RSV seasonality data, we further developed and validated a web-based prediction tool for estimating infant RSV hospitalisation distribution by birth month. Although RSV hospitalisation burden mostly peaked at the second month of life and was concentrated in infants under six months globally, substantial variations were noted in the age distribution of RSV hospitalisation among infants born in different months. Passive immunisation strategies should ideally be tailored to the local RSV disease burden distribution by age and birth month to maximise their per-dose effectiveness before a universal immunisation can be achieved.

Indexed as

HospitalizationRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAge FactorsBayes TheoremHumansInfantInfant, NewbornSeasons

Identifiers

PMID40610449
PMCPMC12229519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.