ArticleNPJ breast cancer2025
Use of membrane lipidome, body weight, and composition in stratification of early breast cancer patients.
Article in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Role of TRAIL in mediating the effect of lipidome on breast cancer: a Mendelian randomization study.Translational cancer research · 2026Article
- Lipid Metabolic Reprogramming in Breast Cancer: Mechanisms and Emerging Therapeutic Strategies.Breast cancer (Dove Medical Press) · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fat quality and quantity have a strong impact on cancer metabolism, however, in oncology practice, only body mass index (BMI) is evaluated. The observational prospective study performed at Fondazione Policlinico Gemelli explored the combination of membrane lipidome, BMI, and body composition, together with nutritional information, as evaluation criteria of fifty newly diagnosed early breast cancer patients (BRECALIP study). The fatty acid content of red blood cell membrane phospholipids, dividing patients by the BMI, individuated normal weight subjects for their molecular signatures different from the other groups, pointing to increased membrane fluidity and inflammation (saturated fatty acid decrease, omega-6 fatty acid increase), known to sustain cancer proliferation. Fat mass (FM% ≥30) and phase angles (PA° ≥ 5.6) in the normal weight group correlated with specific pro-inflammatory fatty acid modifications. Such patient stratification, confirmed by large and longitudinal studies, can better individuate nutritional/metabolic risks of inflammatory implications in breast cancer.
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Registered trials
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