Evidence map›Paper›PMID 40610438›Full record

Trial reportTranslational psychiatry2025

Individual stress reactivity predicts alcohol craving and alcohol consumption in alcohol use disorder in experimental and real-life settings.

Judith Zaiser, Sabine Hoffmann, Sina Zimmermann, Tatjana Gessner, Milena Deck, Nina Kim Bekier, Martin Abel, Philipp Radler, Jens Langejürgen, Bernd Lenz and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Judith ZaiserDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany. judith.zaiser@zi-mannheim.de.ORCID http://orcid.org/0009-0003-2863-8284
Sabine HoffmannDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Sina ZimmermannDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Tatjana GessnerDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Milena DeckDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Nina Kim BekierDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Martin AbelDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Philipp RadlerFraunhofer Institute for Manufacturing Engineering and Automation IPA, Mannheim, Germany.
Jens LangejürgenFraunhofer Institute for Manufacturing Engineering and Automation IPA, Mannheim, Germany.
Bernd LenzDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6086-0924
Sabine Vollstädt-KleinDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6210-672X
Jan StallkampMannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Clemens KirschbaumDepartment of Psychology, Technical University Dresden, Dresden, Germany.
Falk Kiefer *Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.
Patrick Bach *Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5962-019X

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 402170461
6 · The paper itself

Abstract

Stress- and alcohol cues trigger alcohol craving and alcohol consumption in alcohol use disorder (AUD). However, their interactions on a physiological and psychological level and their effects on daily alcohol craving and alcohol use in real-life situations are not understood yet. We conducted a randomized-controlled experimental study to compare the effects of psychosocial stress against physical stress and a control intervention, each followed by an alcohol cue-exposure, on alcohol craving, subjective stress and saliva cortisol levels (main outcomes) in N = 121 individuals with AUD and collected data on daily alcohol use and craving during a 1-year ambulatory assessment phase. We applied linear mixed models to compare the effects of experimental interventions on the main outcomes and the relative contributions of the observed changes on the main outcomes to predicting stress and alcohol craving during the experiment and alcohol use and craving during the ambulatory assessment phase. Sequential exposure to psychosocial stress and alcohol cues induced higher cortisol levels (F

Indexed as

Alcohol DrinkingAlcoholismCravingStress, PsychologicalAdultCuesFemaleHumansHydrocortisoneMaleMiddle AgedSalivaYoung AdultHydrocortisone

Identifiers

PMID40610438
PMCPMC12229504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.