Evidence map›Paper›PMID 40610434›Full record

ArticleCell death & disease2025

Transglutaminase 2 function in glioblastoma tumor efferocytosis.

Margarita Lui, Filiz Sevinc, Mara Elgafarawi, David G Munoz, Jeffrey W Keillor, John Sinclair, Dragosh Catana, Meshari Alhuthayl, John Woulfe, Ian Aj Lorimer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Margarita LuiCancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Filiz SevincCancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID http://orcid.org/0009-0008-9587-8794
Mara ElgafarawiCancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
David G MunozDepartment of Pathology, St. Michael's Hospital, Toronto, ON, Canada.
Jeffrey W KeillorDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0002-8133-6862
John SinclairDepartment of Surgery, University of Ottawa, Ottawa, ON, Canada.
Dragosh CatanaDepartment of Surgery, University of Ottawa, Ottawa, ON, Canada.
Meshari AlhuthaylDepartment of Surgery, University of Ottawa, Ottawa, ON, Canada.
John WoulfeDepartment of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada.
Ian Aj LorimerCancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. ilorimer@ohri.ca.ORCID http://orcid.org/0000-0002-2128-348X

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 162180
6 · The paper itself

Abstract

Glioblastoma is an aggressive and incurable type of brain cancer. Regions of tissue necrosis are a distinctive pathological feature of this cancer. These arise through thrombosis of tumor vasculature, driven by tumor-derived pro-coagulation factors. In studies of transglutaminase 2 (TGM2), we observed that TGM2 mRNA expression in glioblastoma was primarily in a subset of tumor-infiltrating myeloid cells with hypoxia gene expression signatures. Analysis of xenograft and human glioblastoma samples by immunohistochemistry showed that macrophages in the vicinity of necrotic regions expressed very high levels of TGM2. These macrophages were engaged in the phagocytosis of apoptotic cells, a process known as efferocytosis. In cell culture, incubation of macrophages with apoptotic cells induced TGM2 expression in macrophages, and TGM2 inhibitors blocked efferocytosis. In patient-derived glioblastoma organoids cultured in 5% O

Indexed as

Brain NeoplasmsGlioblastomaGTP-Binding ProteinsPhagocytosisTransglutaminasesAnimalsApoptosisCell Line, TumorEfferocytosisHumansMacrophagesMiceOrganoidsProtein Glutamine gamma Glutamyltransferase 2GTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2TGM2 protein, humanTransglutaminases

Identifiers

PMID40610434
PMCPMC12229499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.