Evidence map›Paper›PMID 40610432›Full record

ArticleNature communications2025

Immune correlates of anti-BCMA CAR-T products idecabtagene vicleucel and ciltacabtagene autoleucel in a real-world cohort of patients with multiple myeloma.

Djordje Atanackovic, Tim Luetkens, Dina Schneider, Peirong Hu, Xu Wang, Amol C Shetty, Luke Tallon, Imari Patel, Rohan Singh, Etse Gebru and 17 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
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  11. CD4Nature medicine · 2026
    Article
  12. Review
  13. Article
  14. Robust CD4medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Djordje AtanackovicUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA. datanackovic@som.umaryland.edu.ORCID http://orcid.org/0000-0003-4747-488X
Tim LuetkensUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7085-9027
Dina SchneiderLentigen Technology Inc., a Miltenyi Biotec Company, Gaithersburg, MD, USA.ORCID http://orcid.org/0000-0001-7130-7374
Peirong HuLentigen Technology Inc., a Miltenyi Biotec Company, Gaithersburg, MD, USA.
Xu WangLentigen Technology Inc., a Miltenyi Biotec Company, Gaithersburg, MD, USA.
Amol C ShettyInstitute for Genome Sciences (IGS), School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8790-7649
Luke TallonInstitute for Genome Sciences (IGS), School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA.
Imari PatelUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Rohan SinghUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Etse GebruUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Rediet MulatuUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Destiny OmiliUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Daniel YamoahUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Xiaoxuan FanUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-0501-771X
Aerielle MatsangosUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Patricia LeshoUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Kenneth A DietzeDepartment of Microbiology and Immunology, University of Maryland, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8069-0210
Ariel A FromowitzUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Kim G HankeyUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1699-6087
Saurabh DahiyaStanford University, Stanford, CA, USA.
Jean A YaredUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Nancy M HardyUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Rima KokaDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Michael E KallenDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Ashraf BadrosUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Aaron P RapoportUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Mehmet H KocogluUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Vu H. Duong · 2008 to 2026
$51.0M
NCI NIH HHS P30 CA134274U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA134274
6 · The paper itself

Abstract

We performed the first in-depth, comparative and prospective biomonitoring of Multiple Myeloma (MM) patients (N = 39) receiving ciltacabtagene autoleucel (cilta-cel) or idecabtagene vicleucel (ide-cel) chimeric antigen receptor T cells (CAR T) in the real-world setting. In cilta-cel patients response rates were higher and atypical neurotoxicities/infections more frequent. Peak CAR T counts were significantly higher in cilta-cel patients, driven by CD4

Indexed as

Antigens, CD19B-Cell Maturation AntigenBiological ProductsImmunotherapy, AdoptiveMultiple MyelomaReceptors, Chimeric AntigenAgedCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesT-LymphocytesAntigens, CD19B-Cell Maturation AntigenBiological Productsidecabtagene vicleucelReceptors, Chimeric Antigen

Identifiers

PMID40610432
PMCPMC12229333

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.