Evidence map›Paper›PMID 40610406›Full record

ArticleNature communications2025

Ultrasensitive imaging-based sensor unlocked by differential guided-mode resonance.

Zhenchao Liu, Houxin Fan, Tingbiao Guo, Qin Tan, Zhi Zhang, Yuwei Sun, Julian Evans, Junbo Liang, Ruili Zhang, Sailing He

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenchao Liu *Centre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China.
Houxin Fan *Centre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China.
Tingbiao GuoCentre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China. tbguo@zju.edu.cn.ORCID http://orcid.org/0000-0002-4036-164X
Qin TanCentre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China.
Zhi ZhangCentre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China.
Yuwei SunCentre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China.
Julian EvansCentre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China.
Junbo LiangTaizhou Institute of Medical Health and New Drug Clinical Research, Taizhou Enze Medical Center (Enze), Taizhou Hospital, Zhejiang University, Taizhou, 318000, People's Republic of China.
Ruili ZhangTaizhou Institute of Medical Health and New Drug Clinical Research, Taizhou Enze Medical Center (Enze), Taizhou Hospital, Zhejiang University, Taizhou, 318000, People's Republic of China.
Sailing HeCentre for Optical and Electromagnetic Research, Enze-ZJU Joint Lab for MedEngInfo Collaborative Innovation, College of Optical Science and Engineering, Zhejiang University (ZJU), Hangzhou, 310058, People's Republic of China. sailing@kth.se.ORCID http://orcid.org/0000-0002-3401-1125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging-based sensors convert physicochemical parameters of analytes into visible patterns, yet a high sensitivity remains constrained. Here, we introduce the concept of differential guided-mode resonance with thickness modulation at a tens-nanometer scale to greatly enhance the sensitivity, alleviating the sensitivity-dynamic range tradeoff. Experimental results reveal a sensitivity of up to a million-level pixels per refractive index unit (RIU), surpassing existing technologies by nearly three orders of magnitude, with a large dynamic range reconfigured by the incident angle. With the present method, a moderate value (about 100) of the Q factor suffices to make a record high sensitivity and the Figure of Merit (FOM) can reach 10

Identifiers

PMID40610406
PMCPMC12229338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.