Evidence map›Paper›PMID 40610342›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Gamma activation spread reflects disease activity in amyotrophic lateral sclerosis.

Michael Trubshaw, Katie Yoganathan, Chetan Gohil, Charlotte J Stagg, Anna C Nobre, Kevin Talbot, Mark Woolrich, Alexander G Thompson, Martin R Turner

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael TrubshawOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK. Electronic address: Michael.trubshaw@ndcn.ox.ac.uk.
Katie YoganathanOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Chetan GohilOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.
Charlotte J StaggOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Anna C NobreOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.
Kevin TalbotNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Mark WoolrichOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.
Alexander G ThompsonNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Martin R TurnerOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK. Electronic address: martin.turner@ndcn.ox.ac.uk.

Funding

Department of Health NIHR203316Medical Research Council MR/K01014X/1Wellcome Trust 203139
6 · The paper itself

Abstract

objectiveA non-invasive measure of cerebral motor system dysfunction would be valuable as a biomarker in amyotrophic lateral sclerosis (ALS). Task-based magnetoencephalography (tMEG) measures the magnetic fields generated by cortical neuronal oscillatory activity during task performance. Gamma activations are periods of high-power and high-frequency cortical oscillations integral to motor control.

methodstMEG was undertaken during 60 bilateral isometric hand grip exercises in ALS (n = 42) and compared with healthy controls (HC, n = 33). Gamma activation spread (GAS) was estimated by calculating the number of activated regions during each 100 ms time-bin and compared statistically between groups. Gamma activation patterns were visualised by plotting each participant's brain activity separately as a 2-dimensional video.

resultsThere was no difference in grip strength between groups. GAS was greatly increased in the ALS group compared to HC (p < 0.001) and correlated positively with rate of ALSFRS-R progression (t = 1.35, p = 0.023) and a fine motor sub-score (t = -1.18, p = 0.047).

conclusionsALS was associated with a marked increase in regional spread of gamma frequency activation, greater in those with higher disease progression rates. SIGNIFICANCE: The regional spread of gamma activity may reflect disease activity in ALS, with potential application as an experimental medicine readout.

Indexed as

Amyotrophic Lateral SclerosisGamma RhythmMotor CortexAdultAgedDisease ProgressionFemaleHand StrengthHumansMagnetoencephalographyMaleMiddle AgedALSAmyotrophic lateral sclerosisMagnetoencephalographyMEGMotor taskNeuronal activity

Identifiers

PMID40610342
PMCPMC7618725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.