Observational studyThe journal of obstetrics and gynaecology research2025
A retrospective observational study of changes in uterine fibroid blood flow and fibroid diameter after administration of gonadotropin-releasing hormone agonists and antagonists using superb microvascular imaging.
Observational study in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A retrospective observational study of changes in uterine fibroid blood flow and fibroid diameter after administration of gonadotropin-releasing hormone agonists and antagonists using superb microvascular imaging.The journal of obstetrics and gynaecology research · 2025Observational
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13 authors.
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Abstract
aimThe relationship between the changes in fibroid blood flow and fibroid diameter during the administration of GnRH agonists and antagonists was examined using superb microvascular imaging (SMI).
methodsChanges in the maximum fibroid blood flow and diameter at weeks 0, 2, 4, and 8 were compared between the relugolix, a GnRH antagonist, and leuprolide, a GnRH agonist, groups.
resultsData were collected for 16 fibroids from 12 patients in the relugolix group and 12 fibroids from 9 patients in the leuprorelin group. A significant decrease was observed in the fibroid diameter at 8 weeks in the relugolix group, but no significant change was observed at any time point in the leuprorelin group. In the relugolix group, a significant correlation were observed between changes in blood flow at 2 weeks and fibroid diameter changes at 2 and 4 weeks, and between changes in blood flow at 4 weeks and fibroid diameter changes at 4 weeks. No significant correlation was observed in the leuprorelin group.
conclusionIn the treatment of uterine fibroids with relugolix, a reduction in fibroid blood flow assessed by SMI may suggest a subsequent reduction in fibroid size. These results provide useful insights when making the decision whether or not to continue relugolix administration.
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