Evidence map›Paper›PMID 40610054›Full record

ArticleThe European respiratory journal2025

Functional sequence variants of intergenic long noncoding RNA on chromosome 17q21 are associated with asthma.

Kwei-Yan Liu, Jia-Jyun Sie, Yajing Gao, Yen-Li Lo, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin and 22 more

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Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Kwei-Yan LiuNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Jia-Jyun SieInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yajing GaoNHC Key Laboratory of Neonatal Diseases, Department of Critical CareMedicine, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Yen-Li LoInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chao-Chien WuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Chin-Chou WangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Chau-Chyun SheuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-7979-3749
Ruay-Sheng LaiDivision of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Sum-Yee LeungDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-1266-9281
Chi-Cheng LinChest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan.
Yu-Feng WeiDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Ching-Hsiung LinDivision of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Sheng-Hao LinDivision of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Jeng-Yuan HsuDivision of Clinical Research, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Wei-Chang HuangDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID https://orcid.org/0000-0002-9733-5899
Chia-Cheng TsengDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Yung-Fa LaiDivision of Chest Medicine, Department of Internal Medicine, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan.
Meng-Hsuan ChengDepartment of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Huang-Chi ChenDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Jen YangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yuan-Ting HsuNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Chian-Heng SuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shih-Chang HsuEmergency Department, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1010-1182
Wen-Yu ChungDepartment of Computer Science and Information Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan.
Ming-Tsuen HsiehDepartment of Marine Environment and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-1320-9199
Li-Chen ChenDepartment of Pediatrics, New Taipei City Municipal Tu-Cheng Hospital, Taipei, Taiwan.
Chih-Hsing HungDepartment of Pediatrics, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chon-Lin LeeDepartment of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ming-Shyan HuangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yufeng ZhouNHC Key Laboratory of Neonatal Diseases, Department of Critical CareMedicine, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6050-4951
Cathy S J FannInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Shau-Ku HuangNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan skhuang1@gmail.com.

Funding

HSRD VA CDA 10-014
6 · The paper itself

Abstract

backgroundThe genetic and molecular basis of asthma remains unclear and its gene-environment interaction is still enigmatic. In the present study, we aimed to identify asthma-causing genetic variants and their interactions with the environment.

methodsWe performed case-control genome-wide association studies on individuals of Han Chinese descent from the Taiwan Biobank (n=4877 cases, n=98 218 controls) to identify asthma susceptibility loci, validated in a hospital-based population of subjects (n=2595). The 10-15-year exposures to cumulative ambient particulate matter with a diameter of <2.5 μm (PM

resultsChromosome 17q12-21 was found to be a significant risk region, encompassing variants of

conclusionA functional variant of lncRNA,

Indexed as

AsthmaChromosomes, Human, Pair 17RNA, Long NoncodingAdultAgedCase-Control StudiesEast Asian PeopleFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedParticulate MatterPolycyclic Aromatic HydrocarbonsParticulate MatterPolycyclic Aromatic HydrocarbonsRNA, Long Noncoding

Identifiers

PMID40610054
PMCPMC12528778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.