Evidence map›Paper›PMID 40610053›Full record

ArticleThe European respiratory journal2026

Greater disease severity in adults with paediatric-onset

Luai Khalaili, Stefano Aliberti, Kateryna Viligorska, Francesco Blasi, Nili Stein, Raya Cohen, Rafea Zoubi, Yochai Adir, Alessandro De Angelis, Benjamin Jaaming New and 3 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Luai KhalailiPulmonology Institute, Carmel Medical Center, Haifa, Israel.
Stefano AlibertiRespiratory Unit, Istituto di Ricovero e Cura a Carattere Scientifico Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0002-0090-4531
Kateryna ViligorskaDivision of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Francesco BlasiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-2285-9970
Nili SteinDepartment of Epidemiology and Community Health, Carmel Medical Center, Haifa, Israel.
Raya CohenPulmonology Institute, Carmel Medical Center, Haifa, Israel.
Rafea ZoubiPulmonology Institute, Carmel Medical Center, Haifa, Israel.
Yochai AdirPulmonology Institute, Carmel Medical Center, Haifa, Israel.
Alessandro De AngelisDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Benjamin Jaaming NewDivision of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.ORCID https://orcid.org/0000-0002-1692-8204
Lewis MarshallDivision of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
James D ChalmersDivision of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.ORCID https://orcid.org/0000-0001-5514-7868
Michal ShteinbergPulmonology Institute, Carmel Medical Center, Haifa, Israel michalsh@technion.ac.il.ORCID https://orcid.org/0000-0002-0432-3398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYoung adults with paediatric-onset bronchiectasis (POBE) represent a minority of bronchiectasis patients and are poorly characterised. We aimed to compare the characteristics and severity of adults with POBE to adult-onset bronchiectasis (AOBE).

methodsData from four EMBARC (European Multicentre Bronchiectasis Audit and Research Collaboration) centres were analysed. POBE was defined as patient-reported symptom onset before the age of 18 years, while AOBE was defined as symptom onset at or after the age of 18 years. We compared POBE to AOBE and used multivariable models to identify factors associated with disease severity, including lung function,

resultsAmong 1422 patients, 249 (17.5%) had POBE (mean onset age: 6.5 years) and 1173 had AOBE (mean onset age: 55.4 years). POBE patients were younger at enrolment (50.3

conclusionsAdults with POBE exhibit greater disease severity than those with AOBE, likely due to prolonged symptom duration and congenital aetiologies. Conventional bronchiectasis severity scores may underestimate severity in young people with POBE. Optimised care, including structured transition to adult care, may mitigate progression in POBE patients.

Indexed as

BronchiectasisAdolescentAdultAgedAge of OnsetChildDisease ProgressionEuropeFemaleForced Expiratory VolumeHospitalizationHumansMaleMiddle AgedMultivariate AnalysisPseudomonas aeruginosa

Identifiers

PMID40610053
PMCPMC12824631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.