Evidence map›Paper›PMID 40610001›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Exogenous estradiol increases cardiovagal baroreflex sensitivity during a hypertensive stimulus in premenopausal young women.

Rauchelle E Richey, Jennifer A Miner, Jonathon C Miner, Vienna E Brunt, Paul F Kaplan, John R Halliwill, Christopher T Minson

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rauchelle E RicheyDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.ORCID 0000-0002-7090-1782
Jennifer A MinerDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.
Jonathon C MinerDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.
Vienna E BruntDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.ORCID 0000-0002-1941-7936
Paul F KaplanDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.
John R HalliwillDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.ORCID 0000-0003-3001-1715
Christopher T MinsonDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.ORCID 0000-0003-3459-3708

Funding

Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Progesterone and Vascular Function in WomenR01HL081671 · NHLBI · UNIVERSITY OF OREGON · PI MINSON, CHRISTOPHER TODD · 2008 to 2011
$1.3M
HHS | NIH | National Center for Research Resources (NCRR) UL1TR000128HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL081671NCATS NIH HHS UL1 TR000128NHLBI NIH HHS R01 HL081671University of Oregon (UO) Kenneth M. and Kenda H. Singer Endowed Professorship
6 · The paper itself

Abstract

Women have a greater reduction in cardiovagal baroreflex sensitivity (CVBRS) as they age which contributes to an elevated cardiovascular disease risk. One potential contributor to the attenuated CVBRS may be reductions in estrogen. Therefore, we tested the hypothesis that isolated estradiol (E

Indexed as

BaroreflexEstradiolHypertensionPremenopauseProgesteroneVagus NerveAdultBlood PressureFemaleHeart RateHumansNitroprussideYoung AdultEstradiolNitroprussideProgesteroneautonomic nervous systemblood pressureestradiolgonadotropin-releasing hormone antagonist (GnRHa)progesterone

Identifiers

PMID40610001
PMCPMC12416364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.