ArticleBiochimica et biophysica acta. Molecular cell research2025
GlycoRNA-L and glycoRNA-S mediate human monocyte adhesion via binding to Siglec-5.
Article in Biochimica et biophysica acta. Molecular cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Orthodox vs. Paradox: Supporting the Central Dogma With Sugar Code.Proteomics · 2026Review
- Protocol for identifying glycosylated RNAs using solid-phase chemical conjugation and glycosidase release.STAR protocols · 2026Article
- Novel Organelle-Based Intracellular Immunity with Mechanistic and Therapeutic Implications.Barrier immunity · 2026Article
- PREDICTOR: A Non-Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs.Journal of extracellular vesicles · 2026Article
- Lectin-based detection and expression profiling of native glycoRNAs.Scientific reports · 2026Article
- AquIRE reveals the mechanisms of clinically induced RNA damage and the conservation and dynamics of glycoRNAs.Nucleic acids research · 2026Article
- Review
- GlycoRNA research: from unknown unknowns to known unknowns.Protein & cell · 2026Review
- GlycoRNAs: Biological functions and novel antiviral targets.Virologica Sinica · 2026Article
- Functional regulation of GlycoRNA and progress in malignant tumors.Journal of translational medicine · 2026Review
- Glycosylated RNAs: discovery and implications in cancer biology.Frontiers in oncology · 2026Review
- Cell surface RNAs define a new interface for immune recognition.Frontiers in immunology · 2026Review
- Integration of Mendelian randomization and transcriptome wide association studies for causal gene identification in ovarian cancer genetic architecture.Discover oncology · 2025Article
- State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation.bioRxiv : the preprint server for biology · 2025Article
- GlycoRNA: A new player in cellular communication.Oncology research · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
It was recently reported that RNAs can be glycosylated, and such glycosylated RNAs (referred to as glycoRNAs) are located on the outer cell surface. We here reported that there are two forms of glycoRNAs, named as glycoRNA-L and glycoRNA-S, robustly expressed in human monocytes. We verified that the glycoRNA-S specifically detected in human monocytes is synthesized by enzyme-catalyzed conjugation, but not artificial products of labelling probe. RNase-treatment removed both glycoRNA-L and glycoRNA-S, suggesting that they are localized on cell surface. Removing glycoRNAs significantly suppressed the interaction of human monocytes with endothelial cells, suggesting that glycoRNAs mediate human monocyte adhesion. Using flow cytometry, immunoprecipitation and northern blotting we identified Siglec-5 as the binding receptor of glycoRNAs. Siglec-5 is expressed in human endothelial cells but presented on endothelial cell surface when endothelial cells are activated. We observed that glycoRNA-L was heavily labeled with sialic acid, whereas glycoRNA-S was heavily labeled with N-acetylgalactosamine and N-acetylglucosamine. Together, these results demonstrate that two forms of glycoRNAs exist in human monocytes, which may play significant role in controlling the interaction of human monocytes and endothelial cells and contribute to the pathogenesis of inflammatory diseases.
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