Evidence map›Paper›PMID 40609840›Full record

ArticleInternational journal of radiation oncology, biology, physics2026

Improving Stereotactic Body Radiation Therapy by Rewiring Immunosuppressive Neutrophils in Murine Pancreatic Ductal Adenocarcinoma.

Joseph D Murphy, Gary Hannon, Bradley N Mills, Angela L Hughson, Taylor P Uccello, Nicholas W Gavras, Jian Ye, Brian A Belt, Maggie L Lesch, Sarah L Eckl and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Joseph D MurphyDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Gary HannonDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Bradley N MillsDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Angela L HughsonDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Taylor P UccelloDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Nicholas W GavrasDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Jian YeDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Brian A BeltDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Maggie L LeschDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Sarah L EcklDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Elena B BarrDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Edith M LordDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Minsoo KimDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Haoming QiuDepartment of Radiation Oncology, University of Rochester Medical Center, Rochester, New York.
David C LinehanDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Scott A GerberDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York; Department of Surgery, University of Rochester Medical Center, Rochester, New York. Electronic address: Scott_gerber@urmc.rochester.edu.

Funding

SToP Cancer SPORE: Developmental Research ProgramP50CA257911 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jen Jen Yeh · 2022 to 2026
$12.9M
The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
Targeting adrenergic stress pathways to Increase tumor sensitivity to radiation and promote development of an anti-tumor immune responseR01CA236390 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI GERBER, SCOTT ANDREW, REPASKY, ELIZABETH A · 2019 to 2023
$2.8M
Development of a New Strategy to Treat Locally Advanced Pancreatic CancerR01CA230277 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW · 2019 to 2023
$2.0M
Repolarizing the Tumor and Metastatic Microenvironments to Treat Patients with Pancreatic CancerR01CA262580 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW, LINEHAN, DAVID C · 2021 to 2025
$1.6M
Targeting Intrinsic and Extrinsic Barriers to Treat Metastatic Pancreatic CancerR01CA295861 · NCI · UNIVERSITY OF ROCHESTER · PI Darren Richard Carpizo, Scott Andrew Gerber · 2025 to 2026
$1.3M
NCI NIH HHS P50 CA257911NCI NIH HHS R01 CA230277NCI NIH HHS R01 CA236390NCI NIH HHS R01 CA262580NCI NIH HHS R01 CA295861NIAID NIH HHS T32 AI007285
6 · The paper itself

Abstract

purposeDeciphering the role of neutrophils to radiation response in pancreatic ductal adenocarcinoma (PDAC).

methodsUsing a murine model of PDAC, mice were treated with a clinically- relevant regime of targeted stereotactic body radiation therapy (SBRT). Neutrophil infiltration and activation status were assessed by flow cytometry and immunohistochemistry. Depletion studies were used to determine their role in overall treatment response. Finally, microspheres containing IL-12 cytokine were employed following SBRT to therapeutically repolarize these cells.

resultsFollowing SBRT, neutrophils infiltrated PDAC tumors in high numbers and largely exhibited an immunosuppressive phenotype. Depletion studies confirmed their role in acquired radioresistance, as SBRT efficacy was improved in their absence. Delivering IL-12 cytokine following SBRT could repolarize these cells to be immunostimulatory and enhance anti-tumor immunity in this model.

conclusionNeutrophils are key players in SBRT and IL-12 treatment and can act as a double-edged sword depending on the treatment employed.

Indexed as

Carcinoma, Pancreatic DuctalInterleukin-12Neutrophil InfiltrationNeutrophilsPancreatic NeoplasmsRadiosurgeryAnimalsMiceMice, Inbred C57BLMicrospheresRadiation ToleranceInterleukin-12

Identifiers

PMID40609840
PMCPMC13317819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.