ArticleDevelopmental cell2025
Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process.
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Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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Who cites it
6 citing papers in PubMed.
- From developmental origins to relapse: molecular and therapeutic insights in medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Meningeal-tumor interactions define distinct modes of leptomeningeal colonization in Group 3 medulloblastoma.Acta neuropathologica communications · 2026Article
- Medulloblastoma stem cell programs: Molecular roadmaps of disease progression.Developmental cell · 2026Review
- The tumor microenvironment of medulloblastoma: from emerging biological insights to novel therapeutic targeting.Frontiers in oncology · 2026Review
- National multicentered retrospective review of salvage therapy for pediatric medulloblastoma: a Canadian experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Only the strong survive: therapeutic selective pressure drives medulloblastoma leptomeningeal metastasis.Molecular oncology · 2025Article
Corrections and comments
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Authors and funding
49 authors.
Carolina NörDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada. Electronic address: carolina.nor@sickkids.ca.
Kaitlin KharasDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Alex RasnitsynDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Maria C VladoiuDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Nam Woo ChoDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA; Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jacob S YoungDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Felipe NörDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Ncedile MankahlaDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Joonas HaapasaloDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Kristiina NordforsDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Sara RapicPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Patryk SkowronDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Raúl A SuárezDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Alexander T BahcheliComputational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Oliver OcsenasDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Xin ChenDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Shahrzad BahrampourDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Ali MominDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Lakshmikirupa SundaresanDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Winnie OngDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Liam D HendrikseDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Namal AbeysundaraDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Kyle JuraschkaDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Michelle LyDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Jonelle G PallotaDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Tajana DouglasDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Ning HuangDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Hao WangDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Esta MakDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Lei QinDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Jessica LiuDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Lily ShenDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Betty LuuDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Alex MannoDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Sachin A KumarDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Laura K DonovanDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada.
Vernon FongDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Cory RichmanDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Craig DanielsDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics, Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.
Livia GarziaDepartment of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Jeremy N RichHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Cynthia HawkinsArthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Xiaochong WuDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics, Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.
Ralph DaCostaDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Jüri ReimandDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Xi HuangDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Vijay RamaswamyDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada. Electronic address: vijay.ramaswamy@sickkids.ca.
David R RaleighDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. Electronic address: david.raleigh@ucsf.edu.
Michael D TaylorDevelopmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics, Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA; Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Texas Children's Hospital, Houston, TX, USA. Electronic address: michael.taylor@bcm.edu.
Funding
Mouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4MCCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastomaR01CA255369 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARZIA, LIVIA, TAYLOR, MICHAEL D. · 2021 to 2025
$3.9MPrevention and treatment of lethal metastases in group 3 medulloblastomaR01NS106155 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2018 to 2022
$2.8MUCSF Paul Calabresi K12 Career Development Program in Clinical OncologyK12CA260225 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERGSLAND, EMILY K, BIVONA, TREVER G · 2021 to 2025
$2.6MNCI NIH HHS K12 CA260225NCI NIH HHS R01 CA159859NCI NIH HHS R01 CA255369NINDS NIH HHS R01 NS106155
Abstract
Leptomeningeal metastases are the most important source of morbidity and mortality for medulloblastoma patients. Radiation of the entire brain is highly effective in the treatment and/or prevention of medulloblastoma leptomeningeal metastases. Infants treated on clinical trials with focal tumor radiation recur metastatically, whereas infants treated with only chemotherapy relapse locally. In murine medulloblastoma model systems, provision of a single dose of radiation to the tumor drives leptomeningeal dissemination. An inflammatory response after radiation-induced tumor cell death recruits a variety of immune cells. Inflammation opens the local blood-brain barrier, allowing intravasation of medulloblastoma cells. Experimental induction of inflammation with lipopolysaccharide drives medulloblastoma leptomeningeal dissemination, whereas premedication with corticosteroids prevents both inflammation and the pro-metastatic effect of radiation. In murine model systems, inflammation in the tumor microenvironment secondary to external beam radiation is both sufficient and necessary to drive leptomeningeal metastases.
Indexed as
Cerebellar NeoplasmsImmunity, InnateMedulloblastomaMeningeal NeoplasmsAnimalsBlood-Brain BarrierDisease Models, AnimalHumansInflammationMiceTumor Microenvironmentcytokinesdexamethasoneinflammationleptomeningeal metastasismedulloblastomametastasisradiation
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