Evidence map›Paper›PMID 40609539›Full record

ArticleCell reports. Medicine2025

Augment proteasome inhibitor efficacy activates CD8

Dongyang Tang, Shiqi Lin, Jingbo Zhou, Josh Haipeng Lei, Fangyuan Shao, Heng Sun, Xiangpeng Chu, Ling Li, Lin He, Yunfeng Qiao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Proteasome: Role in T Cell Function Regulation.International journal of biological sciences · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Dongyang TangCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Shiqi LinCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Jingbo ZhouCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China; Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Josh Haipeng LeiCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Fangyuan ShaoCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Heng SunCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Xiangpeng ChuCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Ling LiCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Lin HeCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Yunfeng QiaoCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Xiaoling XuCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China.
Chu-Xia DengCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Center for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau SAR, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China. Electronic address: cxdeng@um.edu.mo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although three proteasome inhibitors are used for liquid tumor treatment, their effectiveness against solid tumors remains inadequate. To address this issue, we employ a drug combination strategy and discover that ammonium tetrathiomolybdate (TM) and AMD3100 can sensitize solid cancer cell lines to proteasome inhibitors. Mechanistically, we find that TM and AMD3100 reduce proteasome activity by decreasing the protein level of PSMB5. This reduction occurs through the activation of the AMP-activated protein kinase (AMPK) pathway, which inhibits STAT3 phosphorylation. Notably, our in vivo studies reveal that drug combinations retard tumor growth dependent on CD8

Indexed as

Breast NeoplasmsCD8-Positive T-LymphocytesProteasome InhibitorsAMP-Activated Protein KinasesAnimalsBortezomibCell Line, TumorChemokine CCL5Drug SynergismFemaleHumansMicePhosphorylationProteasome Endopeptidase ComplexSTAT3 Transcription FactorAMP-Activated Protein KinasesBortezomibChemokine CCL5Proteasome Endopeptidase ComplexProteasome InhibitorsSTAT3 Transcription Factorantigen presentationbreast cancerCCL5immunotherapyproteasome inhibitor

Identifiers

PMID40609539
PMCPMC12281435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.