ArticleCell metabolism2025
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression.
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Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A 4-guanidinobutanoic acid-SLC36A1 axis drives a microbiota‒host feedback loop to regulate intestinal homeostasis.Gut microbes · 2026Article
- The microbiome regulates host metabolic health and diseases through microbial enzymes.Nature reviews. Gastroenterology & hepatology · 2026Review
- Renaissance of Traditional Mineral Drugs in Cancer: Advanced Delivery Strategies and Bioengineering Approaches.Pharmaceutics · 2026Review
- Depression-induced systemic C16-ceramide deficiency promotes OSCC via attenuation of mitochondrial apoptosis.Cellular and molecular life sciences : CMLS · 2026Article
- Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategies.Cancer biology & medicine · 2026Review
- Lipid metabolism reprogramming shapes the immune landscape in the tumor microenvironment.Cellular & molecular immunology · 2026Review
- Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage-Induced Mitochondrial Apoptosis and Parthanatos-Like Cell Death.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- EREG promotes colorectal cancer progression and immune suppressive microenvironment formation through IL-17A/NF-κB pathway.Discover oncology · 2026Article
- Gut microbial metabolites in colorectal cancer: dual roles in tumorigenesis, immune crosstalk, and therapeutic innovation.Frontiers in cellular and infection microbiology · 2026Review
- Plasma Sphingolipid Profiling Predicts Radiosensitivity in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Article
- Gut microbial metabolites in inflammation-associated colorectal cancer: mechanisms and therapeutic implications.Frontiers in microbiology · 2026Review
- Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020.Frontiers in oncology · 2025Article
- GPR35-mediated metabolic reprogramming promotes tumorigenesis in digestive cancers.Frontiers in immunology · 2025Review
- Microbial metabolites and their influence on the tumor microenvironment.Frontiers in immunology · 2025Review
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Authors and funding
28 authors.
Ruize QuDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Yi ZhangDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Bora KimCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Guangyi ZengDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, State Key Laboratory of Female Fertility Preservation and Promotion, Peking University Third Hospital, Beijing 100191, China.
Pengcheng WangCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China.
Weike ShaoyongDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China.
Ying HuangDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China.
Wanwan GuoDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China.
Yang ChenCAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Ping WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Qing YangDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Siyi LuDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Xin ZhouDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Jing WengDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Jinkun XuDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing 100191, China.
Jun LinDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing 100191, China.
Kai WangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing 100191, China.
Yanpeng MaDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Shogo TakahashiCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Yuhong LuoCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Xiaoting YuCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Kristopher W KrauszCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Yanli PangInstitute of Advanced Clinical Medicine, Peking University, Beijing 100191, China; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, State Key Laboratory of Female Fertility Preservation and Promotion, Peking University Third Hospital, Beijing 100191, China.
Tianpei HongDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China.
Zhipeng ZhangDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Department of General Surgery, Peking University Third Hospital, Beijing 100191, China. Electronic address: zhangzhipeng06@126.com.
Wei FuDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Department of General Surgery, Peking University Third Hospital, Beijing 100191, China. Electronic address: fuwei@bjmu.edu.cn.
Frank J GonzalezCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: gonzalef@mail.nih.gov.
Lulu SunDepartment of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China; Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China. Electronic address: lulusun@bjmu.edu.cn.
Funding
Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9MXenobiotic ReceptorsZIABC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$16.4MXenobiotic ReceptorsZ01BC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 1996 to 2008
$1.7MXenobiotic-Metabolizing EnzymesZ01BC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 1996 to 2008
$1.3MTRANSCRIPTIONAL REGULATION OF GENES ENCODING XENOBIOTIC METABOLIZING ENZYMESZ01BC005561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK · 1996 to 2008
$754kLiver-Enriched Transcription FactorsZIABC005561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2010
$500kIntramural NIH HHS Z01 BC005561Intramural NIH HHS Z01 BC005562Intramural NIH HHS Z01 BC005708Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC005561Intramural NIH HHS ZIA BC005562Intramural NIH HHS ZIA BC005708
Abstract
Ceramide metabolism dysregulation links to colorectal cancer (CRC) progression, yet the mechanism remains unknown. d18:1/26:0 ceramide (C26) levels were elevated in patients with CRC and mouse models, which activated epidermal growth factor receptor (EGFR) by binding its extracellular region to promote cancer cell proliferation. The rise of C26 levels was mainly driven by heightened ceramide synthase 3 (CERS3) activity. High CERS3 expression generally accelerated tumor progression, yet some patients exhibited significant heterogeneity, suggesting endogenous metabolites available to affect CERS3 activity. We found that the abundance of Bacteroides cellulosilyticus affects tumor heterogeneity by producing riboflavin that inhibits CERS3 activity, thus delaying CRC progression. Moreover, aclidinium bromide, an FDA-approved drug, exhibited significant inhibitory effects on CERS3 activity, suggesting its potential application in CRC treatment. These findings elucidate the metabolic pathways and mechanisms underlying ceramide's impact on CRC, highlighting that targeting CERS3 inhibition represents a promising therapeutic strategy for CRC.
Indexed as
CeramidesColorectal NeoplasmsRiboflavinSphingosine N-AcyltransferaseAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleHumansMaleMiceOxidoreductasesCeramidesdihydroceramide desaturaseOxidoreductasesRiboflavinSphingosine N-Acyltransferase
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