Evidence map›Paper›PMID 40609403›Full record

ArticleCell calcium2025

Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice.

Yuan Lin, Yang Bai, Alejandro Martin-Avila, Wei Li, Xujun Wu, Edward Ziff, Wen-Biao Gan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuan LinDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, NY, NY 10065, USA.
Yang BaiInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Alejandro Martin-AvilaDepartment of Physiology and Neuroscience, Langone Medical Center, New York University, NY, NY 10016, USA.
Wei LiSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Xujun WuInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Edward ZiffDepartment of Biochemistry and Molecular Pharmacology, Langone Medical Center, New York University, NY, NY 10016, USA. Electronic address: Edward.Ziff@nyulangone.org.
Wen-Biao GanInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen 518132, China; Lingang Laboratory, Shanghai 200031, China. Electronic address: wbgansky@gmail.com.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Mechanisms and therapeutics of calcium dysregulation and synapse loss in Alzheimer's diseaseR21AG064273 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GAN, WENBIAO, ZIFF, EDWARD B · 2019 to 2020
$466k
NCI NIH HHS P30 CA008748NIA NIH HHS R21 AG064273
6 · The paper itself

Abstract

introductionPresenilin (PS) gene mutations cause memory impairment in early-onset familial Alzheimer's disease (FAD), but the underlying mechanisms remain unclear.

methodsWe examined the effects of the PS1 M146V FAD mutation on motor learning, motor learning-related changes in neuronal Ca

resultsWe found that PS1 M146V knock-in mice displayed long-term deficiencies in motor skill learning. Ca DISCUSSION: These findings suggest that alterations of Ca

Indexed as

CalciumCyclic AMP Response Element-Binding ProteinMemory DisordersMutationPresenilin-1Alzheimer DiseaseAnimalsGene Knock-In TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMotor CortexNeuronsPhosphorylationCalciumCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinPresenilin-1Alzheimer’s diseaseCreb phosphorylationIn vivo Ca(2+) imagingMemory deficitsPresenilin 1

Identifiers

PMID40609403
PMCPMC12374543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.