Evidence map›Paper›PMID 40609167›Full record

ArticlePsychiatry research. Neuroimaging2025

Comparison of overnight trends in relative power for specific frequency bands, sleep stages, and brain regions between patients with depressive disorder and matched control subjects.

Leping Li, Amlan Talukder, Deryck Yeung, Yuanyuan Li, David M Umbach, John H Gilmore, Zheng Fan

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leping LiBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: li3@niehs.nih.gov.
Amlan TalukderBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Deryck YeungBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Yuanyuan LiBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
David M UmbachBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
John H GilmoreDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zheng FanDivision of Sleep Medicine and Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

BioinformaticsZIAES101765 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LI, LEPING · 2009 to 2025
$21.0M
BioinformaticsZ01ES101765 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LI, LEPING · 2004 to 2008
$1.1M
Intramural NIH HHS Z01 ES101765Intramural NIH HHS ZIA ES101765
6 · The paper itself

Abstract

Most EEG studies of MDD examined mean differences in frequency-band-specific power between MDD patients and control subjects; however, a few studies looked for differences in temporal trends in power. We focused on overnight time trends in relative power using polysomnography studies of 544 patients with MDD and 1662 age- and sex-matched controls. We sought to replicate our finding on MDD with an additional 653 patients with depressive disorder (DD) and 1959 age- and sex-matched controls. For each subject, we estimated trends as regression slopes separately for 180 features defined by six frequency bands, five sleep stages, and six brain regions. Relative theta power during stage 2 (N2) non-rapid eye movement (NREM) sleep in the frontal and central regions of the brain increased more rapidly through time in MDD patients than in controls. Similar upward trends of relative theta power were also statistically significant in DD patients. If validated in a longitudinal study, the time trend in relative theta power in the N2 stage of the NREM sleep could potentially serve as a surrogate biomarker for monitoring the responses of patients with depressive disorders to treatment.

Indexed as

BrainMajor Depressive DisorderSleep StagesAdultCase-Control StudiesElectroencephalographyFemaleHumansMaleMiddle AgedPolysomnographyTheta RhythmEEGMajor depressive disorderMDDPolysomnographyRegressionTheta rhythmsTrajectory

Identifiers

PMID40609167
PMCPMC12291069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.