Evidence map›Paper›PMID 40609165›Full record

ReviewCurrent opinion in neurobiology2025

What's the occasion? Phasic dopamine signaling and interoception.

Mitchell F Roitman, James E McCutcheon

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mitchell F RoitmanDepartment of Psychology, University of Illinois Chicago, 1007 W Harrison St, Chicago, IL, USA. Electronic address: mroitman@uic.edu.
James E McCutcheonDepartment of Psychology, UiT The Arctic University of Norway, Huginbakken 32 9037, Tromsø, Norway. Electronic address: j.mccutcheon@uit.no.

Funding

Modulation of NAc-DA Signaling by Learning Motivational State and PeptidesR01DA025634 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROITMAN, MITCHELL F · 2009 to 2024
$5.1M
NIDA NIH HHS R01 DA025634
6 · The paper itself

Abstract

Phasic dopamine is critically important in reward-related learning and assigns value to actions triggered by cues. Outcomes of actions in turn adjust the probability that a behavior will be repeated. That is, outcomes reinforce behavior-a process that also involves phasic dopamine. The value of actions and their outcomes, though, is ever fluctuating. Internal state-from physiological need through satiation-gates or applies gain to cue-evoked actions and the evaluation of their outcomes. We focus on how interoceptive signals may influence dopamine neurons to modify the phasic signaling underlying cue and reward-directed behaviors. We focus on interoceptive signals that arise from food or fluid deficit since the peripheral hormonal responses to such needs are relatively well established. A puzzle for the field is understanding how slowly accumulating and more tonic-like physiological signals are integrated to tune the brief and tightly time-locked phasic dopamine responses to environmental stimuli.

Indexed as

DopamineDopaminergic NeuronsInteroceptionRewardSignal TransductionAnimalsCuesHumansDopamine

Identifiers

PMID40609165
PMCPMC13198768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.