ArticleChemphyschem : a European journal of chemical physics and physical chemistry2025
Development of Water-Dispersible CuS Nanoparticles for Chemo-Photothermal Therapy and Photoacoustic Application.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Photothermal therapy (PTT) is a promising treatment option for cancer. However, biocompatibility, water dispersibility, and good photoresponsiveness are necessary for photothermal agents to be used in PTT. Herein, a soft chemical approach is reported for the design and development of phosphorylethanolamine-functionalized CuS nanoparticles (PEA-CuS NPs) using phosphorylethanolamine (PEA) as a surface passivation agent for combinatorial chemo-photothermal therapy. X-ray diffraction and transmission electron microscopy analyses proved the successful formation of the green covellite CuS phase with an average particle size of 13 nm, while Fourier transform infrared spectroscopy and light scattering measurements demonstrated their surface functionalization with the PEA ligand. The PEA-CuS NPs have exhibited good photothermal heating efficacy upon irradiation of 980 nm laser light. Moreover, the in vitro studies have shown substantial cellular uptake of PEA-CuS NPs in MCF-7 cell lines and their dose-dependent cytotoxicity (83.3 and 65.4% cell-killing efficacy by 100 and 50 μg mL
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