Evidence map›Paper›PMID 40608982›Full record

ArticleEmerging microbes & infections2025

Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models.

Chidinma Nelson Orji, Naphat Loeanurit, Van-Can Pham, Thi-Hong-Truc Phan, Kowit Hengphasatporn, Yasuteru Shigeta, Altri Diana Putri, Laura Sandra Lello, Andres Merits, Noppadol Wacharachaisurapol and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chidinma Nelson OrjiCenter of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Naphat LoeanuritCenter of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Van-Can PhamCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Thi-Hong-Truc PhanCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Kowit HengphasatpornCenter for Computational Sciences, University of Tsukuba, Ibaraki, Japan.
Yasuteru ShigetaCenter for Computational Sciences, University of Tsukuba, Ibaraki, Japan.
Altri Diana PutriCenter of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Laura Sandra LelloInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Andres MeritsInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Noppadol WacharachaisurapolDepartment of Pharmacology, Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Wanna EiamartChula Pharmacokinetic Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Supeecha WittayalertpanyaDepartment of Pharmacology, Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tanatorn KhotavivattanaCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Warinthorn ChavasiriCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Siwaporn BoonyasuppayakornCenter of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biscoumarin derivatives were evaluated for antiviral activity against chikungunya virus (CHIKV), a re-emerging mosquito-borne alphavirus with no approved treatment. Compounds 3 and 4 demonstrated potent

Indexed as

Antiviral AgentsChikungunya FeverChikungunya virusCoumarinsVirus ReplicationAnimalsChlorocebus aethiopsDisease Models, AnimalFemaleHEK293 CellsHumansMaleMiceRatsVero CellsViral LoadAntiviral AgentsCoumarinsBiscoumarinchikungunya virusefficacymethyltransferasemicemolecular docking

Identifiers

PMID40608982
PMCPMC12305873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.