Evidence map›Paper›PMID 40608679›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis.

Weijie Guo, Sihao Huang, Xiangli Shao, Yuting Wu, Yuan Ma, Shuya Lu, Hanlin Ren, Xuening Zhou, Zhenglin Yang, Mingkuan Lyu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Single-strand DNA is the link between neutrophil extracellular traps and thrombin.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Weijie GuoDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0001-5694-2142
Sihao HuangDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
Xiangli ShaoDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.
Yuting WuDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.
Yuan MaDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.
Shuya LuDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.
Hanlin RenDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.
Xuening ZhouDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0001-9033-8301
Zhenglin YangDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.
Mingkuan LyuDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0001-5989-0886
Yiwei LiuDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-7899-2279
Vernita GordonInterdisciplinary Life Sciences Graduate Programs, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-5989-9378
Jennifer S BrodbeltDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-3207-0217
Tao PanDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
Yi LuDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-1221-6709

Funding

Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic EngineeringR35GM141931 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yi Lu · 2021 to 2026
$3.5M
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological MoleculesR35GM139658 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S. · 2021 to 2025
$2.9M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM141931NIGMS NIH HHS R35 GM139658NIGMS NIH HHS R35 GM141931Welch Foundation (The Welch Foundation) F-0020
6 · The paper itself

Abstract

Neutrophils release neutrophil extracellular traps (NETs) to neutralize infections, a process that also contributes to immunothrombosis. While beneficial in localized infections, excessive NET formation can lead to widespread coagulopathy and organ failure. While the roles of NET-associated proteins such as histones in immunothrombosis are well characterized, NET-derived DNAs are much less known. To address this issue, we report herein the direct interaction between thrombin and DNA scaffolds and further, the identification of short tandem repeats of single-stranded (ATTCC)

Indexed as

DNA, Single-StrandedExtracellular TrapsNeutrophilsThrombinThrombosisHumansDNA, Single-StrandedThrombinDNA–protein interactionimmunothrombosisneutrophil extracellular trapssingle strand DNAthrombin

Identifiers

PMID40608679
PMCPMC12260427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.