ArticleMemorias do Instituto Oswaldo Cruz2025
Trichophyton rubrum inhibits Candida albicans filamentation and its gene expression when grown in biofilms in vitro.
Article in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDermatomycoses are caused by various fungi, including dermatophytes and Candida species, which are the most prevalent in isolated or associated forms. A great number of virulence factors expressed by these fungi are important for infection, and biofilm formation leads to the persistence of these infections.
objectivesThis work aimed to evaluate the dynamics of Candida albicans filamentation genes in biofilms formed by Candida albicans and Trichophyton rubrum.
methodsThe effect of the supernatants on the biofilms was assessed by XTT reduction assay, confocal microscopy, and gene expression profile analysis by real-time polymerase chain reaction (RT-PCR).
findingsThe supernatants did not reduce the metabolic activities or damage the topography of the monospecies biofilms but caused a reduction in their thickness. The filamentation of C. albicans was inhibited when both fungi were cultivated directly. The filamentation genes studied (CPH1, HWP1, and EFG1) were negatively modulated in C. albicans. MAIN
conclusionsOur findings suggest that the antagonistic relationship shown by T. rubrum against C. albicans may be attributed to alterations of C. albicans filamentous genes.
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