Evidence map›Paper›PMID 40608361›Full record

ArticleDiabetes care2025

Understanding Patient Preferences Regarding Limb Salvage for Diabetic Foot Ulcers: A Discrete Choice Experiment.

Lyndsay M O'Hara, Alison D Lydecker, Gwen L Robinson, Nathan N O'Hara, Justin J Kim, Alyson J Littman, Brian M Schmidt, Odessa Addison, David J Margolis, Mary-Claire Roghmann

Abstract read
In one paragraph

Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Benefits of Multi-Disciplinary Limb Preservation Teams.Clinics in podiatric medicine and surgery · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lyndsay M O'HaraVeterans Affairs Maryland Healthcare System, Baltimore, MD.
Alison D LydeckerVeterans Affairs Maryland Healthcare System, Baltimore, MD.ORCID 0009-0002-8147-4146
Gwen L RobinsonVeterans Affairs Maryland Healthcare System, Baltimore, MD.
Nathan N O'HaraDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD.
Justin J KimDivision of Infectious Diseases, Rush University Medical Center, Chicago, IL.
Alyson J LittmanSeattle Epidemiologic Research and Information Center, Department of Veterans, VA Puget Sound Health Care System, Seattle, WA.ORCID 0000-0002-4247-8286
Brian M SchmidtDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Health, Ann Arbor, MI.ORCID 0000-0002-2561-9243
Odessa AddisonVeterans Affairs Maryland Healthcare System, Baltimore, MD.
David J MargolisDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA.
Mary-Claire RoghmannVeterans Affairs Maryland Healthcare System, Baltimore, MD.ORCID 0000-0003-1063-9257

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
NIDDK Diabetic Foot Consortium Clinical Research UnitU01DK119083 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODICA BUSUI (POP-BUSUI), Crystal Murray Holmes · 2018 to 2026
$5.5M
The Role of the Microbiome in Diabetic Foot UlcersK23DK131261 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brian M Schmidt · 2022 to 2026
$1.2M
CSRD VA I01 CX001601NIA NIH HHS P30 AG028747NIDDK NIH HHS K23 DK131261NIDDK NIH HHS K23DK131261 and K23DK131261-03S1NIDDK NIH HHS U01 DK119083VA Clinical Science Research and Development CX-0016-01
6 · The paper itself

Abstract

objectiveDiabetic foot ulcers (DFUs) often lead to amputations. Limb salvage aims to preserve the lower extremity, but the complexity of care and uncertainty of healing can delay patients' return to normal activities. This study aimed to understand military veterans' preferences regarding limb salvage for DFUs, using a discrete choice experiment (DCE). RESEARCH DESIGN AND

methodsA DCE was conducted with 98 veterans with diabetes at the Baltimore Veterans Affairs Medical Center. Participants were presented with 10 choice sets involving different levels of postrecovery mobility, amputation levels, and future surgery risks. These attributes were developed through literature review and interviews. Data were analyzed using a multinomial logit model to estimate the utility of each attribute level and assess preference heterogeneity.

resultsThe study population was older (mean age 69 years), Black (61%), and male (94%). Half (53%) had a prior foot complication. Postrecovery mobility was the most important attribute (relative importance 53%), followed by amputation level (30%) and future surgery risk (18%). Veterans valued mobility highly, with significant utility differences between walking unaided and needing a wheelchair or scooter. They were willing to accept higher amputation levels to improve mobility.

conclusionsPostrecovery mobility is a critical factor for veterans with DFUs, outweighing concerns about amputation level and future surgical risks. It should be a focus of shared decision-making. The study is limited by its single-site setting and study population. Broader research is needed. Understanding patient preferences through DCE can inform more patient-centered approaches to DFU management, potentially improving outcomes and satisfaction.

Indexed as

Diabetic FootLimb SalvagePatient PreferenceAgedAmputation, SurgicalChoice BehaviorFemaleHumansMaleMiddle AgedVeterans

Identifiers

PMID40608361
PMCPMC12368377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.