Evidence map›Paper›PMID 40608284›Full record

ArticleProbiotics and antimicrobial proteins2026

Anti-Pseudomonas aeruginosa Activity of the Scorpion-Derived Peptide GK8.

Zhongjie Li, Huayi Wang, Shasha Li, Bo Deng, Wenlu Zhang, Pengfei Wu, Wanwu Li, Pengyang Xin, Lingyu Zhao, Shegan Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhongjie LiHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China.
Huayi WangHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China.
Shasha LiHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China.
Bo DengHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China.
Wenlu ZhangHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China. z907733270@163.com.
Pengfei WuHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China.
Wanwu LiHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China.
Pengyang XinState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, China. pyxin27@163.com.
Lingyu ZhaoInstitute of Genetics and Developmental Biology, Translational Medicine Institute, School of Basic Medical Sciences, Xi'an Jiao Tong University, Xi'an, 710049, Shaanxi, China. zhaolingyu@xjtu.edu.cn.
Shegan GaoHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China. gsg112258@163.com.

Funding

Key Scientific Research Projects of Henan Province Higher Education Institutions 25A310024Key Technological Breakthrough Projects in Henan Province 242102310253National Natural Science Foundation of China 22271079Research Project from Pingyuan Laboratory 2023PY-ZZ-0201Young Backbone Teachers of Henan Province Colleges and Universities 2024GGJS054
6 · The paper itself

Abstract

The increasing infection and antibiotic resistance of Pseudomonas aeruginosa has become a major threat to public health, making exploring new and effective antimicrobial agents particularly important. In this study, the scorpion-derived cationic peptide GK8 was designed, which showed effectiveness against P. aeruginosa including clinical resistance strains with low hemolytic activity. In the mouse skin subcutaneous infection model, GK8 significantly decreased the number of P. aeruginosa cells and inflammatory infiltration in the infected area. Mechanism research showed that GK8 killed P. aeruginosa in a concentration- and time-dependent manner, damaging the membrane integrity and membrane potential, inducing ROS accumulation, and interacting with nucleic acids. Moreover, GK8 could inhibit the pathogenic factors of P. aeruginosa, including inhibiting adhesion, motility, pyocyanin production, protease and elastase activities, and biofilm formation. Taken together, GK8 could be a potential alternative anti-infective agent against skin infection caused by P. aeruginosa.

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesPseudomonas aeruginosaPseudomonas InfectionsScorpionsAnimalsBiofilmsMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial peptidePseudomonas aeruginosaScorpionSkin infection

Identifiers

PMID40608284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.