Evidence map›Paper›PMID 40608276›Full record

ArticleInternational journal of hematology2025

Clinical features and outcomes of primary ocular adnexal follicular lymphoma: a retrospective analysis.

Shohei Nakamura, Shinichi Makita, Akiko Miyagi-Maeshima, Yoshikazu Hori, Haruhi Makino, Hirokazu Sasaki, Daiki Hattori, Noriko Iwaki, Suguru Fukuhara, Wataru Munakata and 3 more

Abstract read
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In one paragraph

Article in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ocular adnexa follicular lymphoma: clinicopathological study of 23 patients.Virchows Archiv : an international journal of pathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shohei NakamuraDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Shinichi MakitaDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. smakita@ncc.go.jp.
Akiko Miyagi-MaeshimaDepartment of Pathology, National Cancer Center Hospital, Tokyo, Japan.
Yoshikazu HoriDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Haruhi MakinoDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Hirokazu SasakiDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Daiki HattoriDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Noriko IwakiDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Suguru FukuharaDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Wataru MunakataDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Hiroshi IgakiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shigenobu SuzukiDepartment of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Koji IzutsuDepartment of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extranodal follicular lymphoma (FL) demonstrates unique clinicopathological features and prognostic implications, and the clinical characteristics of ocular adnexal FL are poorly documented. In this study, we retrospectively analyzed histologically confirmed cases of ocular adnexal FL at our institution between 1997 and 2019. Of the 261 patients with lymphoma involving the ocular adnexa, 28 had FL, and staging revealed that 10 had primary ocular adnexal FL. Of these 10 patients, one was excluded because of insufficient treatment information. The median age of the remaining nine patients (six women) was 62 (range: 24-81) years. Lesions were located in the orbit (three patients) or conjunctiva (six patients). Three patients had bilateral conjunctival lesions. Eight patients were initially treated with radiotherapy (including one who received radiotherapy after 1.5 years of observation); the other patient remained untreated for 6.4 years. With a median follow-up period of 7.7 years, three of eight patients who received radiotherapy relapsed (two in the contralateral conjunctiva, one in the subcutaneous tissue of the back), and no in-field relapses occurred. The 5-year progression-free and overall survival rates were 75% and 100%, respectively, without histological transformation. In conclusion, primary ocular adnexal FL has a favorable prognosis after radiotherapy and/or watchful waiting.

Indexed as

Conjunctival NeoplasmsEye NeoplasmsLymphoma, FollicularAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedOrbital NeoplasmsPrognosisRetrospective StudiesSurvival RateTreatment OutcomeYoung AdultFollicular lymphomaOcular adnexal follicular lymphomaRadiotherapyWatchful waiting

Identifiers

PMID40608276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.