ArticleApplied biochemistry and biotechnology2025
Molecular Cloning, Optimization of Expression and Functional Characterization of the Global Transcriptional Regulator MosR (Rv0348) of Mycobacterium tuberculosis.
Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In-vivo microarray analysis on murine model of Tuberculosis had identified a novel transcriptional regulator MosR, which regulates the expression of ~ 163 genes, many of which are important for intracellular persistence of dormant Mycobacterium tuberculosis. MosR therefore, may be considered as potential target for anti-tuberculosis drug discovery. In this work, this important regulator has been cloned, expressed, purified to homogeneity, and characterized to some extent. MosR is found to cooperatively bind within the ORF of the previous gene rv0347. The environmental conditions for most favorable interaction between MosR and its cognate DNA are determined to be 8.0 pH, 25 mM NaCl, and 25 ℃ temperature. The equilibrium dissociation constant (K
Indexed as
Identifiers
40608257What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.