Evidence map›Paper›PMID 40608184›Full record

ReviewJournal of natural medicines2025

Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment.

Jianrong Liu, Tianbo Wu, Wei Li, Quanyi Zhao, Dian He

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianrong LiuInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Tianbo WuInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Wei LiInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Quanyi ZhaoInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China. zhaoqy@lzu.edu.cn.ORCID http://orcid.org/0000-0003-1843-6999
Dian HeInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.

Funding

Iran Food and Drug Administration 2022GSMPA0011Natural Science Foundation of Gansu Province of China 22JR5RA507
6 · The paper itself

Abstract

The tumor inflammatory microenvironment plays an important role in tumor development, and the compounds which modulate tumor microenvironment can be able to accelerate tumor cell death. Here, compound 1 was screened and evaluated through both inhibiting cancer cell proliferation and alleviating the inflammation in microenvironment. In the anti-cancer cell proliferation assay, compound 1 displayed strong proliferative inhibition against all six cell lines, with IC

Indexed as

Antineoplastic AgentsGlycyrrhetinic AcidInflammationTumor MicroenvironmentAnimalsApoptosisCell Line, TumorCell ProliferationHCT116 CellsHumansMiceRAW 264.7 CellsAntineoplastic AgentsGlycyrrhetinic AcidAnti-cancerAnti-inflammationGlycyrrhetinic acid derivative

Identifiers

PMID40608184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.