Evidence map›Paper›PMID 40608096›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Effect of therapeutic plasma exchange on amoxicillin, clindamycin, midazolam, and morphine pharmacokinetics in a critically ill child.

André Yaghyazaryan, Valentina Gracchi, Sybrand W J Zielhuis, Elisabeth H Schölvinck, Daan J Touw, Martin C J Kneyber, Paola Mian

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

André YaghyazaryanDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, the Netherlands.
Valentina GracchiDivision of Pediatric Nephrology, Department of Pediatrics, Beatrix Children's Hospital Groningen, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, The Netherlands.
Sybrand W J ZielhuisDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, the Netherlands.
Elisabeth H SchölvinckDepartment of Pediatric Infectious Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, The Netherlands.
Daan J TouwDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, the Netherlands.
Martin C J KneyberDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Beatrix Children's Hospital Groningen, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, The Netherlands.
Paola MianDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, GZ, 9713, the Netherlands. p.mian@umcg.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a 15-year-old boy with severe septic shock and multiple organ failure, requiring intensive care and extracorporeal therapies, including veno-arterial extracorporeal membrane oxygenation, continuous veno-venous hemodiafiltration, and therapeutic plasma exchange. Given their critical role in the clinical management, pharmacokinetics of amoxicillin, clindamycin, midazolam, and morphine were closely monitored. Drug concentrations were measured before, during, and after therapeutic plasma exchange sessions. Despite theoretical predictions, clinically significant reductions in plasma drug concentrations of amoxicillin, clindamycin, and midazolam were observed following therapeutic plasma exchange. This case report emphasizes the necessity of therapeutic drug monitoring to adjust dosing appropriately and optimize patient outcomes.

Indexed as

AmoxicillinAnti-Bacterial AgentsClindamycinMidazolamMorphineMultiple Organ FailurePlasma ExchangeShock, SepticAdolescentAnalgesics, OpioidCritical IllnessDrug MonitoringExtracorporeal Membrane OxygenationHumansMaleAmoxicillinAnalgesics, OpioidAnti-Bacterial AgentsClindamycinMidazolamMorphineAntibioticsPharmacokineticsSedativesTherapeutic drug monitoringTherapeutic plasma exchange

Identifiers

PMID40608096
PMCPMC12549725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.