Trial reportEuropean journal of applied physiology2026
Kinetics of cell-free DNA in response to exogenous and exertional heating in healthy young men.
Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hyperprolactinemia and Brain Health: Exploring the Gut-Brain Axis and Therapeutic Strategies.Molecular neurobiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeCirculating cell-free DNA (cfDNA) is recognized as a relevant biomarker for monitoring the effects of various physiological and pathophysiological factors. To identify the effect of body temperature, we investigated the kinetics of cfDNA in response to two forms of heating.
methodsIn a randomized crossover design, twelve healthy young males cycled at 60% of their maximum oxygen uptake (VO
resultsLinear mixed model analyses revealed a strong significant interaction effect for cfDNA (T
conclusionOur findings demonstrate that an increase in rectal temperature induces physiological stress, which triggers the release of cfDNA, however, at a significantly lower level than exertional heating, suggesting that mechanical stress has a greater influence on the release.
Indexed as
Identifiers
40608069What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.