ArticleLangmuir : the ACS journal of surfaces and colloids2025
Understanding Viral-Glycocalyx Interactions Using Brush-Linked to Cross-Linked Models.
Article in Langmuir : the ACS journal of surfaces and colloids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Arthritis models for studying chikungunya virus joint inflammation.Communications biology · 2026Review
- Glycocalyx at the host-virus interface: a double-edged sword in virus infection and tissue damage.Frontiers in molecular biosciences · 2026Review
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The interaction of viruses with cells is mediated by the glycocalyx, a ubiquitous cell coating layer. Here, we present a study of the effects of the cellular glycocalyx, a complex outer cell structure, on viral internalization. Using both simulations and experiments, we have shown that the structure of the glycocalyx, specifically the number of cross-links within it, can greatly influence the ability of a virus to infect a cell. We show that the presence of the glycocalyx plays a direct role in viral internalization, and targeting the glycocalyx can be a potential avenue for future therapies. Overall, by comparison with experimental results, we conclude that a brush-like glycocalyx model is the more appropriate computational model compared to its partially cross-linked versions.
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Registered trials
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