ReviewInfection and immunity2025
Arginine at the host-pathogen interface.
Review in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization.Nature communications · 2026Article
- The accumulation of methylglyoxal and acrolein impairs arginine homeostasis causing hyperglycemia and renal abnormalities in male zebrafish.Nature communications · 2026Article
- Arginine Decarboxylase Gene (Microorganisms · 2026Article
- Article
- Arginine metabolism has a pivotal function for the encystation of Giardia duodenalis.PLoS pathogens · 2026Article
- Real-time simultaneous monitoring of multiple analytes in bacterial cultures.Applied and environmental microbiology · 2025Article
- Immunometabolism at the crossroads of infection: mechanistic and systems-level perspectives from host and pathogen.Immunometabolism (Cobham, Surrey) · 2025Review
- A regulator of amino acid catabolism controlsbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Nutrient availability shapes the course of infection. Arginine, a conditionally essential amino acid, plays a crucial role in both host immune defense and pathogen metabolism. As a precursor for nitric oxide production, arginine supports immune functions in multiple immune cell types to control infections. However, it also serves as a signal for pathogens that promotes bacterial survival and growth. A plethora of recent studies have shown that arginine functions not only as a metabolic substrate but also as a key environmental cue that can alter cyclic diguanylate levels. Arginine availability regulates multiple bacterial processes in both Gram-positive and Gram-negative species including toxin production, biofilm formation, Type III secretion system, swarming, persistence, and immune evasion. In this way, arginine levels can shape how pathogens behave within the host environment. This review examines how fluctuations in arginine levels across different host niches influence microbial pathogenesis and highlights the complex interplay between arginine availability and bacterial behavior. Understanding the role of arginine in host-pathogen interactions may provide new therapeutic strategies to combat infections by targeting bacterial responses to this crucial nutrient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.