ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2025
Non-invasive characterization of melanoma depth at single-cell resolution.
Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Precision medicine in cutaneous melanoma-A comprehensive review.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- An Ultra-Low-Cost Optoacoustic Method for Imaging Specific Biological Structures.Diagnostics (Basel, Switzerland) · 2026Article
- Ultra-wideband raster-scanning optoacoustic mesoscopy as a histologic-grade tool for melanoma depth assessment.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Non-invasive characterization of melanoma depth at single-cell resolution.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundEfficient staging and management of cutaneous melanoma, one of today's deadliest skin cancers, requires non-invasive determination of tumour depth (Breslow depth). However, current imaging technologies lack the necessary contrast or penetration to measure Breslow depth.
objectivesTo determine if raster-scanning optoacoustic mesoscopy (RSOM) can fill this gap in dermatology.
methodsWe used phantoms to optimize RSOM for melanoma imaging and demonstrated its capability to image melanocytes at single-cell resolution in deep tissue. We then compared RSOM's ability to measure Breslow depth against the clinical standard in a pilot study. For the phantoms studies, we compared the ability of an optimized RSOM system to measure the concentration and diameter of single melanoma cells against gold-standard microscopy methods. For the pilot clinical study, we used linear regression to compare RSOM's Breslow depth against the clinical standard, obtaining the goodness of fit (R
resultsBy utilizing ultra-wideband frequency detection and optimized illumination wavelength, we show that RSOM achieves non-invasive imaging of melanoma at the resolution of single melanocytes, penetrating more than 3 mm into the skin. The agreement between RSOM and the standard-of-care histological assessment was R
conclusionsRSOM provides non-invasive imaging performance that correlates with the Breslow depth determination. Further work is needed to confirm these findings and to test RSOM against other non-invasive methods.
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