ArticlePM & R : the journal of injury, function, and rehabilitation2025
Risk of septic arthritis after corticosteroid joint injections: A retrospective propensity score-matched cohort analysis.
Article in PM & R : the journal of injury, function, and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Musculoskeletal infections in sports: imaging approach, sport-specific risk factors, and diagnostic pitfalls.Skeletal radiology · 2026Review
- Interventional Pain Procedures: A Narrative Review Focusing on Safety and Complications. Part 4 - Peripheral Nerve, Joint, Musculoskeletal, and Regenerative Interventions.Journal of pain research · 2026Review
- Risk of septic arthritis after corticosteroid joint injections: A retrospective propensity score-matched cohort analysis.PM & R : the journal of injury, function, and rehabilitation · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic arthritis (SA) is a rare but serious complication of corticosteroid joint injections (CSI) that can lead to joint damage and possible mortality. There is limited research defining the true risk of SA following large joint corticosteroid injection.
objectiveTo determine the absolute and risks difference of SA after large joint corticosteroid injection.
designA retrospective cohort study of electronic health records identified patients from a multicenter and nationwide database in the United States who had an ambulatory visit with a diagnosis of arthritis. The absolute risk of SA after a large joint corticosteroid injection was calculated, as was the risk difference based on presence or absence of large joint corticosteroid injection. To calculate the risk difference, patients were propensity-score matched (1:1) based on risk factors such as demographics, comorbidities, or nonhealth-related risk factors. The primary outcome was SA diagnosis between 1 and 21 days after the large joint corticosteroid injection. The risk of SA was compared between matched cohorts with 95% confidence intervals (CIs).
resultsThe absolute risk for SA was found to be 0.0018, whereas the risk difference of SA after major joint corticosteroid injection was 0.0010 and the risk without major joint corticosteroid injection was 0.0017. The risk difference for those with a large joint corticosteroid injection compared to the control group was -0.0007 (95% CI, -0.0009 to -0.0005, p < .001).
conclusionCurrent standard practices related to major joint corticosteroid injection do not increase the risk of SA.
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