Evidence map›Paper›PMID 40607769›Full record

ArticleJournal of immunotoxicology2025

Evaluating impacts of the trichloroethylene metabolite

Annella Benjamin, Erica Boldenow, Sammy Jaber, Kelly Bakulski, John Dou, Justin Colacino, Peter Mancuso, Sean Harris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunotoxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annella BenjaminDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Erica BoldenowDepartment of Biology, Calvin University, Grand Rapids, MI, USA.
Sammy JaberDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kelly BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
John DouDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Justin ColacinoDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Peter MancusoDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sean HarrisDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI HARRIS, SEAN M · 2010 to 2024
$38.6M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Diversity SupplementR01ES028802 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 2018 to 2026
$4.8M
Racial inequalities in health throughout adulthood: The cumulative impact of neighborhood chemical and non-chemical stressors on epigenomic pathwaysR01MD013299 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2018 to 2022
$3.7M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
Folic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1M
Characterizing disparities in late-onset Alzheimer's disease risk through polygenic risk and epidemiologic factors in the Health and Retirement SurveyR01AG055406 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2017 to 2020
$1.7M
Q223R Leptin Receptor Polymorphism in Bacterial PneumoniaR21AI180617 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MANCUSO, PETER · 2024 to 2025
$429k
NCI NIH HHS P30 CA046592NIAID NIH HHS R21 AI180617NIA NIH HHS R01 AG055406NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P42 ES017198NIEHS NIH HHS R01 ES025531NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R01 ES028802NIMHD NIH HHS R01 MD013299
6 · The paper itself

Abstract

Trichloroethylene (TCE) is a volatile synthetic chemical used in various industrial processes like metal degreasing. Large amounts of TCE have been released into the environment. Exposure to TCE can occur through routes, such as inhalation for workers using TCE or ingestion of drinking water in contaminated areas. Macrophages are key immune cells in virtually all tissues in the human body, including the fetal membranes, making them a plausible target for DCVC-induced immunotoxicity. Macrophages are critical for maintaining anti-microbial defenses during pregnancy, but little data exists on TCE immunotoxicity during pregnancy. We previously showed that the TCE metabolite,

Indexed as

CysteineCytokinesMacrophagesTrichloroethyleneFemaleHumansPregnancyPregnancy OutcomeTHP-1 CellsTranscriptomeCysteineCytokinesS-(1,2-dichlorovinyl)cysteineTrichloroethylenecytokinesmacrophagePregnancytrichloroethylene

Identifiers

PMID40607769
PMCPMC12335004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.