Evidence map›Paper›PMID 40607579›Full record

ArticleeLife2025

The double-edged nature of trained immunity.

Chrissy M Leopold Wager, Larry S Schlesinger

Abstract readEditorial
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trained immunity in respiratory diseases: Mechanisms of action and intervention strategies.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chrissy M Leopold WagerHost Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, United States.ORCID https://orcid.org/0000-0002-3828-055X
Larry S SchlesingerHost Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, United States.ORCID https://orcid.org/0000-0002-7177-8421

Funding

Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection- Diversity SupplementR01AI136831 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Eusondia A. Arnett, Larry S. Schlesinger · 2019 to 2026
$4.6M
NIAID NIH HHS R01 AI136831
6 · The paper itself

Abstract

Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.

Indexed as

Immunity, InnateMacrophages, AlveolarPneumoniaAnimalsHumansMiceTrained Immunityacute lung injuryalveolar macrophagebeta-glucanimmunologyinflammationmousetrained immunity

Identifiers

PMID40607579
PMCPMC12226015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.