Evidence map›Paper›PMID 40607479›Full record

ArticleIJU case reports2025

Transient Azoospermia Induced by Valganciclovir Treatment for Cytomegalovirus Infection in a Reproductive Male After Kidney Transplant: A Case Report.

Kosuke Mieda, Shunta Hori, Mitsuru Tomizawa, Kuniaki Inoue, Tatsuo Yoneda, Yuji Nitta, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Kiyohide Fujimoto

Abstract read
In one paragraph

Article in IJU case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kosuke MiedaDepartment of Urology Nara Medical University Kashihara, Nara Japan.
Shunta HoriDepartment of Urology Nara Medical University Kashihara, Nara Japan.ORCID https://orcid.org/0000-0001-9514-9964
Mitsuru TomizawaDepartment of Urology Nara Medical University Kashihara, Nara Japan.
Kuniaki InoueDepartment of Urology Nara Medical University Kashihara, Nara Japan.ORCID https://orcid.org/0009-0003-4804-6630
Tatsuo YonedaDepartment of Urology Nara Medical University Kashihara, Nara Japan.
Yuji NittaDepartment of Diagnostic Pathology Nara Medical University Kashihara, Nara Japan.
Yasushi NakaiDepartment of Urology Nara Medical University Kashihara, Nara Japan.ORCID https://orcid.org/0000-0002-7579-0372
Makito MiyakeDepartment of Urology Nara Medical University Kashihara, Nara Japan.ORCID https://orcid.org/0000-0001-9503-7356
Nobumichi TanakaDepartment of Urology Nara Medical University Kashihara, Nara Japan.ORCID https://orcid.org/0000-0001-9242-7877
Kiyohide FujimotoDepartment of Urology Nara Medical University Kashihara, Nara Japan.ORCID https://orcid.org/0000-0003-1507-2464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Spermatogenic dysfunction is a side effect of valganciclovir, which is commonly used to treat cytomegalovirus infections. Here, we report the case of a reproductive man who underwent kidney transplantation and was diagnosed with azoospermia after valganciclovir treatment for cytomegalovirus infection. Case Presentation: A 30-year-old man underwent an ABO-compatible living-donor kidney transplantation. Two months after the kidney transplant, the patient was diagnosed with cytomegalovirus infection and gastritis. Therefore, valganciclovir treatment was initiated. Two months after completion of valganciclovir treatment, the patient was diagnosed with azoospermia. Azoospermia induced by valganciclovir was suspected, and careful monitoring was performed. Nine months after azoospermia diagnosis, the sperm concentration improved to normal range (43.3 × 10 Conclusion: During valganciclovir treatment, careful monitoring and adequate informed consent are needed to support patients of reproductive age.

Indexed as

azoospermiacytomegaloviruskidney transplantationspermatozoavalganciclovir

Identifiers

PMID40607479
PMCPMC12212939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.