Evidence map›Paper›PMID 40607432›Full record

ArticleFrontiers in immunology2025

High NK cell counts at day 90 predict improved survival in event-free patients after T-cell depleted allogeneic stem cell transplantation.

Andrej Pešić, Nevena Bešević, Nicolaus Kröger, Dejana Stanisavljević, Nada Kraguljac Kurtović, Zoran Bukumirić, Natalija Kecman, Nikola Lemajić, Mihailo Smiljanić, Nada Suvajdžić Vuković and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Andrej PešićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Nevena BeševićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Nicolaus KrögerDepartment of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dejana StanisavljevićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Nada Kraguljac KurtovićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Zoran BukumirićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Natalija KecmanClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Nikola LemajićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Mihailo SmiljanićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Nada Suvajdžić VukovićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Andrija BogdanovićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Ana VidovićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Jelena BilaClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Mirjana MitrovićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Danijela LekovićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Marijana VirijevićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Irena ĐunićClinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Darko Antić *Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Milena Todorović Balint *Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Immune reconstitution (IR) after allogeneic stem cell transplantation has been highlighted as pivotal in achieving favorable long-term outcomes by influencing the rates of infection, graft versus host disease (GvHD) and relapse. However, data on the impact of different lymphocyte subsets influencing outcomes is conflicting. Furthermore, the importance of immune reconstitution parameters in patients previously not experiencing major post-transplant complications is lacking. Methods: We evaluated the clinical impact of day 90 NK cell, CD4 Results: High NK cell counts on day 90 (>178/μL) were associated with improved OS (P=0.039) and lower rates of NRM (1-year cumulative incidence of 5.7% versus 31.4%, HR 0.16, 95% CI 0.04-0.69, P=0.014). A protective effect on RI was not found. We found no patient, disease or transplant-related variables to be significantly associated with day 90 NK cell counts. Conclusion: The results suggest that high NK cell counts on day 90 after T-cell depleted allogeneic transplantation independently protect from NRM and improve OS in patients without prior major post-transplant complications.

Indexed as

Hematopoietic Stem Cell TransplantationKiller Cells, NaturalAdultAgedFemaleGraft vs Host DiseaseHumansImmune ReconstitutionLymphocyte CountLymphocyte DepletionMaleMiddle AgedTransplantation, HomologousYoung Adultallogeneic stem cell transplantationimmune reconstitutionNK cellsT-cell depleted grafttransplant outcomes

Identifiers

PMID40607432
PMCPMC12213383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.