Evidence map›Paper›PMID 40607418›Full record

ArticleFrontiers in immunology2025

Neutrophil-lymphocyte and platelet-lymphocyte ratios as systemic inflammatory biomarkers for atopic dermatitis in US adults: a cross-sectional NHANES study revealing subgroup heterogeneity.

Xuanlin Chen, Xiangyu Yang, Min Zhang, Yirui Zhao, Shuping Guo

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuanlin Chen *Department of Dermatology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Xiangyu Yang *Department of Dermatology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Min ZhangDepartment of Dermatology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yirui ZhaoDepartment of Dermatology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Shuping GuoDepartment of Dermatology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are systemic inflammation markers, but their association with adult atopic dermatitis (AD) remains underexplored. Methods: This cross-sectional study analyzed 2001-2006 NHANES data from 10,890 US adults. AD was defined by self-reported physician diagnosis. Cutoffs for NLR (1. 81×10 Results: Elevated NLR (≥1. 81×10 Conclusion: NLR and PLR are accessible systemic inflammatory biomarkers for AD, with subgroup heterogeneity suggesting roles for lymphocyte depletion (skin homing), neutrophilic (Th17), and platelet-mediated (Th2) inflammation pathways.

Indexed as

Blood PlateletsDermatitis, AtopicLymphocytesNeutrophilsAdultBiomarkersCross-Sectional StudiesFemaleHumansInflammationLymphocyte CountMaleMiddle AgedNutrition SurveysPlatelet CountUnited StatesBiomarkersatopic dermatitisbiomarkerneutrophil-to-lymphocyte ratioNHANESplatelet-to-lymphocyte ratiosystemic inflammation

Identifiers

PMID40607418
PMCPMC12213362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.