Evidence map›Paper›PMID 40607414›Full record

ArticleFrontiers in immunology2025

Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells.

Maryam Abooali, Inna M Yasinska, Gauri Thapa, Xi Lei, Kelly A S da Costa, Stephanie Schlichtner, Steffen M Berger, Elizaveta Fasler-Kan, Nigel J Temperton, Romina Vuono and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maryam Abooali *Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Inna M Yasinska *Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Gauri Thapa *Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Xi LeiMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Kelly A S da CostaMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Stephanie SchlichtnerDKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.
Steffen M BergerDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Elizaveta Fasler-KanDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Nigel J TempertonMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Romina Vuono *Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Vadim V Sumbayev *Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last 2 years, there has been an increasing concern that SARS-CoV-2 infection may represent a marker of undiagnosed cancers. A potential connection between COVID-19/long COVID and malignant transformation/cancer progression was reported in a number of studies. It is, however, unclear if the virus itself can cause malignant transformation or if it has a potential to support malignant processes in human body. We analyzed nasopharyngeal swabs collected from individuals infected with Wuhan strain of SARS-CoV-2 and conducted

Indexed as

COVID-19Immune EvasionNeoplasmsSARS-CoV-2B7-H1 AntigenCell LineEpithelial CellsHumansHypoxia-Inducible Factor 1, alpha SubunitIndoleamine-Pyrrole 2,3,-DioxygenaseKetoglutaric AcidsSpike Glycoprotein, CoronavirusB7-H1 AntigenCD274 protein, humanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIndoleamine-Pyrrole 2,3,-DioxygenaseKetoglutaric AcidsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2cancerCOVID-19immune checkpointsimmune evasionSARS-CoV-2

Identifiers

PMID40607414
PMCPMC12213721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.