Evidence map›Paper›PMID 40607404›Full record

ArticleFrontiers in immunology2025

In evolution's unending race: ancestral STING sensors in

Alejandro J Yañez, Jorge F Beltrán, Claudia A Barrientos, Genaro Soto-Rauch, Marcelo Aguilar, Adolfo Isla, Sandra N Flores-Martin, Francisco T Yañez, Yassef Yuivar, Adriana Ojeda and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Time-Resolved Label-Free Proteomics of SHK-1 Cells AfterInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alejandro J YañezDepartamento de Investigación y Desarrollo, Greenvolution SpA, Puerto Varas, Región de Los Lagos, Chile.
Jorge F BeltránDepartment of Chemical Engineering, Universidad de la Frontera, Temuco, Chile.
Claudia A BarrientosLaboratorio de Diagnóstico y Terapia, Vicerrectoría de Investigación, Desarrollo y Creación Artística (VIDCA), Universidad Austral de Chile, Valdivia, Chile.
Genaro Soto-RauchLaboratorio de Diagnóstico y Terapia, Vicerrectoría de Investigación, Desarrollo y Creación Artística (VIDCA), Universidad Austral de Chile, Valdivia, Chile.
Marcelo AguilarInterdisciplinary Center for Aquaculture Research (INCAR), Concepción, Chile.
Adolfo IslaInterdisciplinary Center for Aquaculture Research (INCAR), Concepción, Chile.
Sandra N Flores-MartinLaboratorio de Diagnóstico y Terapia, Vicerrectoría de Investigación, Desarrollo y Creación Artística (VIDCA), Universidad Austral de Chile, Valdivia, Chile.
Francisco T YañezLaboratorio de Diagnóstico y Terapia, Vicerrectoría de Investigación, Desarrollo y Creación Artística (VIDCA), Universidad Austral de Chile, Valdivia, Chile.
Yassef YuivarLaboratorio de Diagnóstico y Biotecnología, ADL Diagnostic Chile, Puerto Montt, Chile.
Adriana OjedaLaboratorio de Diagnóstico y Biotecnología, ADL Diagnostic Chile, Puerto Montt, Chile.
Felipe AlmendrasDepartamento de Investigación y Desarrollo, Greenvolution SpA, Puerto Varas, Región de Los Lagos, Chile.
Patricio BustosLaboratorio de Diagnóstico y Biotecnología, ADL Diagnostic Chile, Puerto Montt, Chile.
Marcos MancillaLaboratorio de Diagnóstico y Biotecnología, ADL Diagnostic Chile, Puerto Montt, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: "In evolution's unending race, survival demands continuous adaptation- to stop is to fall behind." The Stimulator of Interferon Genes (STING) pathway embodies this principle, acting as a conserved master regulator of cytosolic DNA sensing from Methods: We structurally characterized the ancestral STING ortholog from Atlantic salmon ( Results: Our models confirmed evolutionary conservation of key STING structural domains. Docking revealed a strong binding affinity between the human agonist and salmonid STING, supporting translational potential. Transcriptomics showed high Discussion: This study positions

Indexed as

Fish DiseasesFish ProteinsMembrane ProteinsSalmo salarAnimalsEvolution, MolecularHumansMolecular Docking SimulationSignal TransductionFish ProteinsMembrane ProteinsAtlantic salmon-pathogen interactiondynamics activation gene expressionevolutionary perspectivesinnate immune responseSTING genestructural functions

Identifiers

PMID40607404
PMCPMC12213456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.