ArticleRegenerative therapy2025
Influence of extracorporeal shockwaves on macrophage polarization in a 3D collagen matrix.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The host's immune response determines the success of guided tissue regeneration. Extracorporeal shockwave therapy (ESWT) has been shown to reduce inflammation and improve wound healing. Nevertheless, its impact on macrophage polarization, as the first line of host defense, has not yet been elucidated. Therefore, this study aimed to investigate the effect of ESWT on macrophage polarization in a 3D collagen matrix model. Methods: Macrophages were isolated from human donor blood and differentiated into M1 macrophages. The cells were seeded into a collagen gel, and macrophages treated with ESWT (500 impulses, energy flux density 0.12 mJ/mm Results: Flow cytometry revealed no significant differences between the ESWT-treated (+ESWT) and untreated (-ESWT) macrophages for any of the markers. However, macrophages cultured in collagen gel (3) exhibited significantly higher CD200R expression rates than the other groups. Conclusions: The lack of significant differences in macrophage polarization following ESWT in this 3D model may be attributed to the absence of cell-cell interactions and other tissue structures that are present
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.