ArticleAnnals of gastroenterological surgery2025
The impact of delayed adjuvant chemotherapy on survival in gastric cancer patients with and without preoperative chemotherapy.
Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Survival prognostic impact of post-surgical complications in gastric cancer patients after neoadjuvant chemotherapy: a single western center analysis.Updates in surgery · 2026Article
- The impact of delayed adjuvant chemotherapy on survival in gastric cancer patients with and without preoperative chemotherapy.Annals of gastroenterological surgery · 2025Article
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Authors and funding
7 authors.
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Abstract
Aim: Adjuvant chemotherapy (AC) is the standard treatment for patients with advanced gastric cancer (GC), yet the optimal timing for its initiation remains unclear. Besides, no studies have definitively established when AC should begin in patients receiving preoperative chemotherapy (PC). This study aimed to determine the optimal timing for initiating AC in patients with GC who underwent curative gastrectomy, either with or without PC. Methods: A total of 446 patients who underwent curative gastrectomy were evaluated, including 140 who received AC: 72 without PC and 68 with PC. Patients were categorized into two groups based on when they began AC: the early initiation group (within 8 weeks post-surgery), and the late initiation group (8 weeks or later post-surgery). Results: In the non-PC cohort, the 3-year relapse-free survival (RFS) rates were 71% in the early group versus 56% in the late group ( Conclusion: Delayed initiation of AC is associated with significantly poorer postoperative survival in patients with GC, irrespective of whether PC was administered. These findings emphasize the importance of timely AC initiation to improve long-term outcomes in this patient population.
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